SCH 79797 dihydrochloride CAS: 1216720-69-2
MF: C23H25N5•2HCl
MW: 444.40
A strong, selective non-peptide Thrombin R inhibitor.

SCH 79797 dihydrochloride (CAS 1216720-69-2)

SCH 79797 dihydrochloride | CAS 1216720-69-2 is rated 5.0 out of 5 by 1.
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Alternate Names: N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride
Application: SCH 79797 dihydrochloride is a strong, selective non-peptide Thrombin R inhibitor
CAS Number: 1216720-69-2
Purity: ≥99%
Molecular Weight: 444.40
Molecular Formula: C23H25N52HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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SCH 79797 dihydrochloride is a nonpeptide selective inhibitor of Thrombin R (PAR1), a thrombin-activated receptor. PARs have been described as G protein-coupled receptors that regulate endothelial nitric oxide synthase activity via phosphorylation of the enzyme at various sites. SCH 79797 dihydrochloride has also been reported to contain a high affinity for thrombin receptor-activating peptides, such as α-thrombin.


References

1. Ahn, H.S., et al. 2000. Biochem. Pharmacol. 60: 1425-1434. PMID: 11020444
2. Lidington, E.A., et al. 2005. Am. J. Physiol., Cell Physiol. 289: C1437-C1447. PMID: 16079188
3. Strande, J.L., et al. 2007. Basic Res. Cardiol. 102: 350-358. PMID: 17468933
4. Watts, V.L. and Motley, E.D. 2009. Exp. Biol. Med. 234: 132-139. PMID: 19064940

Physical State :
Solid
Solubility :
Soluble in ethanol (25 mM), and DMSO (50 mM).
Storage :
Desiccate at room temperature
Melting Point :
247-248° C
Boiling Point :
678.3° C at 760 mmHg (Predicted)
IC50 :
PAR1 receptor: IC50 = 70 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD04039788
SMILES :
CC(C)C1=CC=C(C=C1)CN2C=CC3=C2C=CC4=C3C(=NC(=N4)NC5CC5)N.Cl.Cl

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Certificate of Analysis

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SCH 79797 dihydrochloride (CAS 1216720-69-2)  Product Citations

See how others have used SCH 79797 dihydrochloride (CAS 1216720-69-2). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 26518435  Tutwiler, V.|Madeeva, D.|Ahn, HS.|Andrianova, I.|Hayes, V.|Zheng, XL.|Cines, DB.|McKenzie, SE.|Poncz, M.|Rauova, L.| et al. 2016. Blood. 127: 464-72.

PMID: # 26475502  Sato, N. et al. 2016. Bone. 83: 23-34.

PMID: # 25958163  Pan, XY.|Peng, L.|Han, ZQ.|Yin, GQ.|Song, YK.|Huang, J.| et al. 2015. Tissue Cell. 47: 301-10.

PMID: # 25645904  Vélez, P. et al. 2015. Scientific reports. 5: 8198.

PMID: # 25701722  Tanaka, Y. et al. 2015. Eur. J. Pharmacol. 752: 97-105.

PMID: # 24177339  Jaber, M. et al. 2014. Cellular and molecular life sciences : CMLS. 71: 2517-33.

PMID: # 24338998  Kim, MS. et al. 2014. Molecular nutrition & food research. 58: 698-708.

PMID: # 24636778  Chen, J. et al. 2014. Stem cell research & therapy. 5: 36.

PMID: # 30054581  Sci Rep. 11320.

PMID: # 24378645  Lab. Invest. 297-308.

Citations 1 to 10 of 10 total
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Rated 5 out of 5 by from Mao Mao, X. et al. (PubMed 25649264) exposed cultured oligodendrocyte precursor cells from rats and mice to blood plasma with and without the PAR1 antagonist SCH-79797. They found interference with the thrombin-PAR1 system does not reduce the adverse effects of blood on germinal cells of the immature rodent brain. -SCBT Publication Review
Date published: 2015-07-03
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