THP Inhibitors
THP inhibitors encompass a diverse array of compounds designed to modulate the function of Tamm-Horsfall protein (THP), a glycoprotein primarily associated with renal function and implicated in various physiological and pathophysiological processes. While direct inhibitors targeting THP are limited, a multitude of compounds exert their effects by influencing cellular processes associated with THP, with a particular focus on the NF-κB pathway and other signaling cascades. Among the indirect inhibitors, Sulfasalazine, JSH-23, and BAY 11-7082 play crucial roles in impacting THP through the regulation of the NF-κB pathway. These compounds disrupt pro-inflammatory signaling cascades and influence THP expression, providing researchers with tools to dissect the intricate interplay between THP and inflammatory responses. Compounds like Celastrol and Wedelolactone, acting as inhibitors of IκB kinase (IKK), a key regulator of NF-κB activation, further contribute to the modulation of THP function. By targeting the NF-κB pathway, these compounds showcase the interconnectedness of THP regulation with inflammatory signaling.
Parthenolide, Andrographolide, Bay 11-7085, and Withaferin A represent additional members of the THP inhibitor class that influence THP through their NF-κB inhibitory properties. These compounds exhibit diverse mechanisms, highlighting the versatility of strategies to modulate THP-mediated responses. Additionally, Dimethyl fumarate, by activating the Nrf2 pathway, indirectly affects THP expression. This compound, with its antioxidant properties, provides an alternative avenue for influencing THP in the context of cellular stress responses. The overall significance of THP inhibitors lies in their capacity to unravel the regulatory mechanisms governing THP function, particularly in the realms of inflammation and cellular stress responses. This chemical class serves as a valuable resource for researchers seeking to selectively modulate THP-mediated cellular responses, offering insights into the physiological and pathophysiological roles of THP. The intricate network of signaling pathways influenced by these inhibitors underscores the complexity of THP regulation and provides a foundation for understanding its multifaceted roles in health and disease.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine is an NF-κB inhibitor that indirectly modulates THP. By inhibiting NF-κB activation, Sulfasalazine disrupts the pro-inflammatory signaling cascade, influencing THP expression and activity. This indirect modulation positions Sulfasalazine as a compound capable of affecting THP function through interference with the NF-κB-mediated regulation of THP-associated pathways. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
JSH-23 is a selective inhibitor of NF-κB nuclear translocation that indirectly influences THP. By blocking NF-κB translocation, JSH-23 interferes with the pro-inflammatory signaling cascade, impacting THP expression and function. This indirect modulation highlights JSH-23 as a compound capable of affecting THP function through interference with the NF-κB-mediated regulation of THP-associated pathways. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is an irreversible inhibitor of IKK-2, a component of the NF-κB pathway, indirectly modulating THP. By inhibiting IKK-2, BAY 11-7082 disrupts NF-κB activation, influencing THP expression and activity. This indirect modulation positions BAY 11-7082 as a compound capable of affecting THP function through interference with the IKK-2-dependent regulation of the NF-κB-mediated pathway associated with THP. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol is a natural compound that inhibits the NF-κB pathway, indirectly influencing THP. By disrupting NF-κB activation, Celastrol impacts the pro-inflammatory signaling cascade, affecting THP expression and function. This indirect modulation positions Celastrol as a compound capable of affecting THP function through interference with the NF-κB-mediated regulation of THP-associated pathways. | ||||||
Wedelolactone | 524-12-9 | sc-200648 sc-200648A | 1 mg 5 mg | $110.00 $337.00 | 8 | |
Wedelolactone is an inhibitor of IκB kinase (IKK) that indirectly modulates THP. By blocking IKK, Wedelolactone disrupts NF-κB activation, influencing THP expression and activity. This indirect modulation positions Wedelolactone as a compound capable of affecting THP function through interference with the IKK-dependent regulation of the NF-κB-mediated pathway associated with THP. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide is an NF-κB inhibitor that indirectly influences THP. By inhibiting NF-κB activation, Parthenolide disrupts the pro-inflammatory signaling cascade, impacting THP expression and function. This indirect modulation positions Parthenolide as a compound capable of affecting THP function through interference with the NF-κB-mediated regulation of THP-associated pathways. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Andrographolide is an NF-κB inhibitor that indirectly modulates THP. By inhibiting NF-κB activation, Andrographolide disrupts the pro-inflammatory signaling cascade, influencing THP expression and activity. This indirect modulation positions Andrographolide as a compound capable of affecting THP function through interference with the NF-κB-mediated regulation of THP-associated pathways. | ||||||
BAY 11-7085 | 196309-76-9 | sc-202490 sc-202490A | 10 mg 50 mg | $124.00 $526.00 | 55 | |
Bay 11-7085 is a derivative of BAY 11-7082 and an irreversible inhibitor of IKK-2, indirectly influencing THP. By inhibiting IKK-2, Bay 11-7085 disrupts NF-κB activation, impacting THP expression and activity. This indirect modulation positions Bay 11-7085 as a compound capable of affecting THP function through interference with the IKK-2-dependent regulation of the NF-κB-mediated pathway associated with THP. | ||||||
Dimethyl fumarate | 624-49-7 | sc-239774 | 25 g | $28.00 | 6 | |
Dimethyl fumarate is an activator of the Nrf2 pathway, indirectly influencing THP. By activating Nrf2, Dimethyl fumarate modulates the antioxidant response, affecting THP expression and function. This indirect modulation positions Dimethyl fumarate as a compound capable of affecting THP function through interference with the Nrf2-mediated regulation of THP-associated pathways. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A is an inhibitor of NF-κB that indirectly influences THP. By blocking NF-κB activation, Withaferin A disrupts the pro-inflammatory signaling cascade, impacting THP expression and function. This indirect modulation positions Withaferin A as a compound capable of affecting THP function through interference with the NF-κB-mediated regulation of THP-associated pathways. | ||||||