Thimet oligopeptidase Activators
Thimet oligopeptidase Activators encompasses a group of compounds that specifically target and modulate the activity of Thimet oligopeptidase (THOP1). THOP1, also known as EC 3.4.24.15, is a metallopeptidase enzyme that plays a pivotal role in the cleavage and degradation of various oligopeptides, especially neuropeptides and peptide hormones, within the nervous and endocrine systems. The activation of THOP1 is integral to the fine-tuning of peptide metabolism and, by extension, various cellular processes that rely on these bioactive molecules.
Thimet oligopeptidase activators are designed to directly engage with the THOP1 enzyme and induce changes in its enzymatic activity. These compounds function as molecular switches, promoting the efficient hydrolysis of specific substrates, often neuropeptides and peptide hormones, or modulating the regulation of THOP1 itself. By interacting with THOP1 at the molecular level, activators can facilitate the precise control of peptide processing. This modulation may be crucial for maintaining the equilibrium of neuropeptide signaling and ensuring that cellular responses are finely tuned to physiological demands. Thimet oligopeptidase activators, therefore, serve as valuable tools in the study of neuropeptide metabolism and the underlying molecular mechanisms, contributing to a deeper understanding of neurobiology and endocrinology. While they hold promise for further research and applications, their utility primarily lies in elucidating the intricate network of pathways that rely on precise peptide regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phosphoramidon | 119942-99-3 | sc-201283 sc-201283A | 5 mg 25 mg | $195.00 $620.00 | 8 | |
A metalloprotease inhibitor that directly activates THOP1 by interacting with its catalytic site, modulating its enzymatic activity, and enhancing peptide metabolism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Indirectly activates THOP1 by stimulating adenylate cyclase, leading to increased cAMP levels. Elevated cAMP directly activates THOP1, enhancing its peptide processing. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Indirectly influences THOP1 through its role in elevating cAMP levels. This directly activates THOP1, affecting post-translational modification and regulation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
Acts as an indirect activator by directly binding to and stimulating PKA. PKA activation directly activates THOP1, impacting neuropeptide metabolism. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Directly influences THOP1 by serving as a calcium ionophore, modulating intracellular calcium levels. THOP1, involved in calcium-dependent peptide processing, is directly activated. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Indirectly activates THOP1 by inhibiting phosphodiesterases, directly increasing cAMP levels. Elevated cAMP directly activates THOP1, enhancing its enzymatic activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Indirectly influences THOP1 by directly binding to and activating GPCRs, modulating the signaling pathways related to neuropeptide regulation, and directly activating THOP1. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Indirectly impacts THOP1 by directly inhibiting dynamin, a key protein in endocytosis. This directly activates THOP1, affecting its involvement in peptide metabolism. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
An indirect activator by directly inhibiting cysteine proteases. This directly alters the protease balance, indirectly affecting THOP1 and peptide metabolism. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Indirectly influences THOP1 by directly inhibiting ribosome function and protein synthesis. This directly activates THOP1 by leading to changes in its levels and potentially affecting its activity directly or indirectly. | ||||||