TFG Activators
TFG Activators are a collection of chemical compounds that enhance the functional activity of the TFG protein. These chemicals exert their effects by acting on the specific signaling pathways that the TFG protein is involved in. For instance, Forskolin and Cilostazol are known to affect the cAMP-dependent pathway, which is one of the pathways TFG is involved in. By increasing the cAMP level in the cell, these compounds indirectly promote protein kinase A (PKA) activation, which can phosphorylate TFG, leading to its enhanced functional activity. Similarly, IBMX maintains higher cAMP and cGMP levels, indirectly promoting PKA activity and subsequently enhancing TFG function.
On the other hand, compounds like LY294002, Wortmannin, U0126, PD98059, Rapamycin and Genistein act by inhibiting specific proteins or pathways, leading to the activation of alternative signaling pathways that can enhance TFG activity. For instance, LY294002 and Wortmannin are inhibitors of PI3K. By inhibiting PI3K, they can activate specific protein kinases that can phosphorylate TFG, thereby enhancing its activity. Similarly, U0126 and PD98059 lead to the activation of alternative signaling pathways that canenhance TFG activity. Rapamycin and Akt Inhibitor VIII, can also lead to the activation of alternative pathways that enhance the activity of TFG.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a potent adenylate cyclase activator that promotes the production of cyclic AMP (cAMP), a second messenger involved in a multitude of cellular processes. An increase in cAMP levels can stimulate protein kinase A (PKA), which is capable of phosphorylating TFG, leading to its enhanced functional activity. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol is a phosphodiesterase III inhibitor that prevents the degradation of cAMP. By maintaining higher cAMP levels, it indirectly promotes PKA activation, leading to TFG phosphorylation and enhanced activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor that prevents the breakdown of cAMP and cyclic GMP (cGMP). This action can help maintain PKA activity, which can phosphorylate and enhance the function of TFG. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA (Phorbol 12-myristate 13-acetate) is a potent activator of protein kinase C (PKC), which can activate multiple downstream signaling proteins, including TFG, thereby enhancing its activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, but at lower concentrations can act as an activator of PKC. By activating PKC, it can stimulate TFG, leading to its enhanced activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. Inhibition of mTOR can lead to the activation of alternative signaling pathways that can phosphorylate and enhance TFG activity. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $204.00 $265.00 | 29 | |
Akt Inhibitor VIII is a potent inhibitor of Akt1/2/3. Its action can lead to the activation of kinases that can phosphorylate and enhance the activity of TFG. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a potent inhibitor of protein tyrosine kinases. Its action can lead to the activation of alternative signaling pathways that can phosphorylate and enhance TFG activity. | ||||||