Tektin 4 Inhibitors
Tektin 4, as a structural component integral to the function of cilia and the sperm tail, is deeply intertwined with microtubule dynamics in cells. This relationship underscores the paramount importance of maintaining microtubular stability and the implications when it's compromised. Within the landscape of compounds known to affect microtubules, Tektin 4 inhibitors stand out for their ability to perturb this stability. Agents like Taxol and Epothilone B operate by stabilizing microtubules, creating an environment where the natural ebb and flow of tubulin assembly and disassembly is halted. This static state imposed upon the microtubules can have cascading effects, disrupting the milieu in which Tektin 4 operates.
Conversely, a broad spectrum of compounds, including Colchicine, Vinblastine, Vincristine, and Nocodazole, pose a contrasting threat by inhibiting microtubule formation. By targeting tubulin, the foundational unit of microtubules, these agents disrupt the very assembly of these structures. Without the formation of these crucial scaffolds, proteins like Tektin 4 can find their functional roles undermined. Additionally, agents such as Maytansine, Rhizoxin, and Dolastatin 10, while also affecting microtubule dynamics, do so through varied and nuanced mechanisms, further underscoring the complexity of interactions in this domain. When viewed collectively, the arsenal of Tektin 4 inhibitors not only highlights the pivotal role of microtubules in cellular functions but also showcases the multifaceted strategies by which they can be modulated, thus influencing the proteins that rely on them.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol, a diterpenoid compound, is renowned for its ability to stabilize microtubules by binding the β-tubulin subunit. Its presence obstructs the natural dynamics of microtubule assembly and disassembly. Given Tektin 4's association with microtubule dynamics in the context of ciliary and flagellar structures, Taxol can perturb its functional context. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine, an alkaloid found in Colchicum autumnale, is known to bind tubulin dimers, preventing their polymerization into microtubules. This suppression can drastically influence proteins like Tektin 4, which are reliant on proper microtubule architecture and function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is an agent that disrupts microtubule dynamics by triggering rapid depolymerization. This interference can alter the natural processes and functions of proteins, like Tektin 4, that have associations with the microtubule network within cells. | ||||||
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $107.00 $404.00 $550.00 $2200.00 | 9 | |
Vinblastine, a vinca alkaloid, operates by binding tubulin and inhibiting its polymerization, stymieing the formation of the microtubule network. The disruption in microtubules can impact proteins like Tektin 4, which rely on these structures for their functions. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin, an antifungal agent, disrupts microtubule functions by interacting with polymerized tubulin, potentially affecting the assembly process. This action can have repercussions for Tektin 4 and its associated roles in the cell. | ||||||
Maytansine | 35846-53-8 | sc-507510 | 100 mg | $1000.00 | ||
Maytansine, an agent, exerts its effect by inhibiting tubulin assembly. Its interference in microtubule formation and dynamics can potentially influence the functional role of Tektin 4 in the cellular milieu. | ||||||
Estramustine | 2998-57-4 | sc-353281 sc-353281A | 100 mg 1 g | $265.00 $743.00 | ||
Estramustine binds tubulin and disrupts its polymerization dynamics, thereby altering the microtubule network. This alteration can influence the structural and functional aspects of Tektin 4, given its association with microtubules. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $45.00 $79.00 | ||
This compound binds to tubulin, disrupting its polymerization dynamics and thus, the architecture of the microtubular network. Proteins like Tektin 4, that are closely associated with microtubules, can experience altered dynamics due to such interference. | ||||||