Date published: 2025-10-22

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TBX4 Activators

TBX4 Activators is a class of chemicals that can indirectly activate TBX4, a transcription factor involved in developmental processes. These activators primarily act on various cellular pathways that TBX4 is associated with, thereby influencing its activity. The class includes a wide range of compounds from different chemical families, exhibiting diverse mechanisms of action.

For instance, compounds such as retinoic acid and dexamethasone modulate the activity of TBX4 by impacting the retinoic acid and glucocorticoid signaling pathways respectively. Through these pathways, they can influence the expression levels of TBX4. Another example is forskolin that works via stimulating adenylate cyclase, thereby increasing cyclic AMP levels. This can indirectly influence the Wnt/β-catenin signaling pathway, which TBX4 is related to. Lithium Chloride, in contrast, is a known inhibitor of GSK3β, a negative regulator of the Wnt/β-catenin pathway. By inhibiting GSK3β, it can indirectly upregulate TBX4. Further, some chemicals in this class can influence TBX4 activity by affecting cellular processes. 2-Deoxy-D-glucose, a glucose analog, inhibits glycolysis and can indirectly affect cellular processes that TBX4 is involved in. Sodium Butyrate is a HDAC inhibitor that can modify chromatin structure and affect gene transcription, including potentially TBX4. Genistein is a tyrosine kinase inhibitor that can indirectly affect signal transduction pathways associated with TBX4. Lastly, curcumin, with multiple targets including NF-kB and AP-1 transcription factors, can modulate a variety of signaling pathways indirectly affecting TBX4. These diverse mechanisms highlight the complex nature of cellular signaling and the potential indirect routes to affect TBX4 activity.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Retinoic acid can modulate the activity of TBX4 by affecting the retinoic acid signaling pathway, which in turn influences the expression levels of TBX4.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin stimulates adenylate cyclase, thereby increasing cyclic AMP levels. This can indirectly influence the Wnt/β-catenin signaling pathway, which TBX4 is related to.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$76.00
$82.00
$367.00
36
(1)

Dexamethasone, a glucocorticoid, can influence the glucocorticoid signaling pathway. Indirect effects on TBX4 could potentially occur through this pathway.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Lithium Chloride is a known inhibitor of GSK3β, which is a negative regulator of the Wnt/β-catenin pathway. By inhibiting GSK3β, it can indirectly upregulate TBX4.

Insulin

11061-68-0sc-29062
sc-29062A
sc-29062B
100 mg
1 g
10 g
$153.00
$1224.00
$12239.00
82
(1)

Insulin can activate the PI3K/AKT pathway, which can indirectly affect the activity of TBX4.

2-Deoxy-D-glucose

154-17-6sc-202010
sc-202010A
1 g
5 g
$65.00
$210.00
26
(2)

2-Deoxy-D-glucose is a glucose analog that inhibits glycolysis and can indirectly affect cellular processes that TBX4 is involved in.

Metformin

657-24-9sc-507370
10 mg
$77.00
2
(0)

Metformin activates the AMPK pathway, which may have an indirect effect on TBX4 activation.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$30.00
$46.00
$82.00
$218.00
19
(3)

Sodium Butyrate is a HDAC inhibitor that can modify chromatin structure and affect gene transcription, including potentially TBX4.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein is a tyrosine kinase inhibitor that can indirectly affect signal transduction pathways associated with TBX4.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$182.00
$693.00
88
(1)

Y-27632 inhibits Rho kinase, a key regulator of actin cytoskeleton, which indirectly affects cellular processes linked to TBX4.