TBX10 Inhibitors
Chemical inhibitors of TBX10 function through various mechanisms to modulate the activity of this transcription factor. Palbociclib, by inhibiting CDK4/6, can arrest the cell cycle in the G1 phase, which is critical for TBX10 activity related to cell cycle-dependent transcriptional regulation. Similarly, Y-27632, a ROCK inhibitor, can alter cytoskeletal dynamics, potentially affecting the nuclear-cytoplasmic trafficking of TBX10, thereby impacting its activity within the nucleus. SB431542, an inhibitor of the TGF-β receptor, can disrupt the downstream signaling pathways with which TBX10 interacts to regulate gene expression. This mechanism may reduce TBX10's role in mediating responses to TGF-β signals.
Further influencing TBX10 activity, LY294002 and Wortmannin, both PI3K inhibitors, can diminish Akt phosphorylation and activity, which may be necessary for TBX10's transcriptional functions. PD0325901 and U0126, as MEK inhibitors, block the MAPK/ERK pathway, which could lead to decreased ERK activation and a subsequent reduction in TBX10-mediated transcriptional activity. In the context of cellular stress responses, SP600125, a JNK inhibitor, can inhibit the modulation of TBX10 activity in stress-related gene expression. Additionally, Dorsomorphin, an AMPK and BMP signaling inhibitor, and LDN-193189, a BMP type I receptor inhibitor, can decrease TBX10's transcriptional activity by interfering with BMP signaling pathways. Lastly, XAV-939 and IWP-2 interfere with the Wnt/β-catenin pathway, with XAV-939 inhibiting tankyrase enzymes and IWP-2 preventing Wnt ligand secretion, both of which are important for TBX10's potential regulatory roles downstream of Wnt activation. These inhibitors collectively contribute to the modulation of TBX10's transcriptional influence within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib is a CDK4/6 inhibitor. Since TBX10 is a transcription factor implicated in cell cycle regulation, palbociclib can inhibit the cell cycle progression at the G1 phase, which could reduce TBX10 activity as TBX10 may be involved in cell cycle-dependent transcriptional regulation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor. ROCK has been shown to influence cytoskeletal dynamics, which can affect the localization and function of transcription factors. Inhibition of ROCK may thus lead to altered nuclear-cytoplasmic trafficking of TBX10, functionally inhibiting its activity within the nucleus. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is an inhibitor of the TGF-β receptor. TBX10, by its nature as a transcription factor, may interact with proteins downstream of the TGF-β pathway. Inhibition of this pathway could reduce TBX10's ability to regulate gene expression in response to TGF-β signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. The PI3K/Akt pathway is involved in multiple cellular processes including transcription. Inhibiting PI3K can reduce Akt phosphorylation and activity, which may be necessary for full TBX10 transcriptional activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is a JNK inhibitor. JNK is involved in cellular stress responses and can modulate transcription factor activity. Inhibiting JNK may impede TBX10's role in stress-related gene expression. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is also a MEK inhibitor with a similar mechanism of action as PD0325901. It can block the MAPK/ERK pathway, potentially reducing TBX10's activity in cells where this pathway is part of TBX10's functional mechanism. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
Dorsomorphin is an AMPK inhibitor, and also known to inhibit BMP signaling. TBX10's activity could be linked to BMP signaling pathways, and inhibition of this pathway could reduce TBX10-mediated transcriptional responses to BMP signals. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV-939 is a Wnt/β-catenin pathway inhibitor, specifically inhibiting tankyrase enzymes. As TBX10 is a transcription factor, it's conceivable that Wnt signaling influences its activity. Inhibiting Wnt signaling may reduce TBX10's transcriptional influence. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
IWP-2 is an inhibitor of Wnt production, preventing Wnt ligand secretion. By diminishing Wnt signaling, TBX10's potential regulatory roles downstream of Wnt activation can be functionally inhibited. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
LDN-193189 is a BMP type I receptor inhibitor, which can block BMP signaling. BMP signaling may be important for TBX10's function in transcription, and its inhibition can decrease TBX10's transcriptional activity. | ||||||