TAZ Activators
TAZ, a key effector of the Hippo signaling pathway, plays a critical role in cellular processes such as proliferation, differentiation, and tissue homeostasis. While direct activators of TAZ are limited, several chemicals indirectly modulate TAZ activity by affecting its subcellular localization and transcriptional activity. Verteporfin, a YAP/TAZ-TEAD interaction inhibitor, prevents TAZ nuclear translocation and transcriptional activation. Simvastatin, an HMG-CoA reductase inhibitor, indirectly activates TAZ by upregulating its expression through the mevalonate pathway. Epigallocatechin gallate (EGCG) inhibits TAZ activity by disrupting its nuclear localization and transcriptional activity. 2-Methoxyestradiol, a derivative of estradiol, inhibits TAZ by modulating its nuclear localization and transcriptional activity.
Cytochalasin D and Latrunculin B indirectly influence TAZ by disrupting the actin cytoskeleton, a regulator of TAZ localization and function. Dasatinib inhibits TAZ phosphorylation, influencing its localization and downstream signaling pathways. Blebbistatin, Fasudil, and Bleomycin indirectly modulate TAZ through the regulation of the actin cytoskeleton, Rho kinase activity, and Hippo pathway activation, respectively. AICAR, an AMP-activated protein kinase activator, influences TAZ activity through AMPK-mediated regulation of cellular energy status. PF-573228, a focal adhesion kinase inhibitor, modulates TAZ activity by influencing focal adhesions and associated signaling pathways. These chemicals offer insights into strategies for manipulating TAZ activity, contributing to our understanding of cellular regulation and research avenues.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Simvastatin is an HMG-CoA reductase inhibitor that indirectly activates TAZ. It has been shown to upregulate TAZ expression through the mevalonate pathway, leading to increased TAZ activity in certain cellular contexts. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol found in green tea. EGCG has been reported to inhibit TAZ activity by disrupting its nuclear localization and reducing its transcriptional activity. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $70.00 $282.00 | 6 | |
2-Methoxyestradiol is a derivative of estradiol. It inhibits TAZ by disrupting its nuclear localization and inhibiting its transcriptional activity, leading to the modulation of downstream target genes. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D is a fungal metabolite that disrupts the actin cytoskeleton. By affecting cytoskeletal dynamics, Cytochalasin D indirectly influences TAZ activity. The actin cytoskeleton is known to play a role in the regulation of TAZ localization and function. | ||||||
Latrunculin B | 76343-94-7 | sc-203318 | 1 mg | $229.00 | 29 | |
Latrunculin B is a toxin that disrupts actin polymerization. Its impact on the actin cytoskeleton indirectly influences TAZ activity, as the actin cytoskeleton is involved in the regulation of TAZ nuclear localization and transcriptional activity. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin is a myosin II inhibitor that indirectly modulates TAZ activity by influencing actin dynamics. The actin cytoskeleton, regulated by myosin II, plays a role in TAZ localization and function. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an AMP-activated protein kinase (AMPK) activator. By activating AMPK, AICAR influences TAZ activity through the AMPK-mediated regulation of cellular energy status and downstream signaling cascades. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Bleomycin is an antitumor antibiotic that indirectly influences TAZ activity. It has been reported to activate the Hippo pathway, leading to the phosphorylation and inactivation of TAZ. | ||||||