TAAR5 Inhibitors
TAAR5 (Trace Amine-Associated Receptor 5) inhibitors belong to a class of chemical compounds that specifically target and modulate the activity of the TAAR5 receptor, a member of the trace amine-associated receptor family. These receptors are G-protein-coupled receptors (GPCRs) found in various tissues throughout the body, including the olfactory epithelium and the gastrointestinal tract. TAAR5 receptors are particularly notable for their role in detecting and responding to trace amines, a group of biogenic amines present in low concentrations in the body. While trace amines themselves have been linked to various physiological functions and neurotransmission, the precise role of TAAR5 in these processes remains an area of ongoing research.
TAAR5 inhibitors are designed to selectively block or modulate the activity of the TAAR5 receptor, either by binding to the receptor and altering its conformation or by interfering with downstream signaling pathways. By doing so, these inhibitors can influence the perception of specific odors or tastes related to trace amines or impact other physiological responses mediated by TAAR5 activation. The development and study of TAAR5 inhibitors have provided valuable insights into the molecular mechanisms underlying chemosensory perception and the interplay between GPCRs and their ligands. Understanding the function of TAAR5 receptors and their regulation through these inhibitors may have broader implications in the field of sensory neuroscience and may offer new avenues for exploring the complexities of olfaction, taste, and related physiological processes, although further research is needed to fully elucidate the extent of their effects and applications beyond the realm of taste and smell perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $60.00 | 2 | |
3′-Azido-3′-deoxythymidine, also known as AZT, is a nucleoside reverse transcriptase inhibitor. It interferes with the reverse transcription step of HIV replication by incorporating into the growing viral DNA chain, leading to chain termination. | ||||||
Lamivudine | 134678-17-4 | sc-221830 sc-221830A | 10 mg 50 mg | $102.00 $214.00 | 1 | |
Lamivudine is another nucleoside reverse transcriptase inhibitor. It inhibits HIV replication by being incorporated into the viral DNA, causing premature chain termination during reverse transcription. | ||||||
Tenofovir | 147127-20-6 | sc-204335 sc-204335A | 10 mg 50 mg | $154.00 $633.00 | 11 | |
Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor. It is phosphorylated within infected cells and competes with natural nucleotides, leading to chain termination in viral DNA synthesis. | ||||||
Efavirenz | 154598-52-4 | sc-207612 | 10 mg | $168.00 | 3 | |
Efavirenz is a non-nucleoside reverse transcriptase inhibitor. It binds directly to the reverse transcriptase enzyme, disrupting its function and inhibiting viral replication. | ||||||
Raltegravir | 518048-05-0 | sc-364600 sc-364600A sc-364600B sc-364600C sc-364600D | 5 mg 50 mg 100 mg 500 mg 1 g | $100.00 $821.00 $1229.00 $2861.00 $4085.00 | 21 | |
Raltegravir is an integrase strand transfer inhibitor. It blocks the integration of viral DNA into the host genome by binding to the integrase enzyme, preventing the formation of stable DNA-virus complexes. | ||||||
S/GSK1349572 | 1051375-16-6 | sc-364605 sc-364605B sc-364605A | 5 mg 50 mg 200 mg | $367.00 $1484.00 $4131.00 | ||
S/GSK1349572 is an integrase strand transfer inhibitor. It inhibits the integration of viral DNA into the host genome by binding to and inhibiting the integrase enzyme. | ||||||
Darunavir | 206361-99-1 | sc-218079 | 5 mg | $311.00 | 4 | |
Darunavir is a protease inhibitor that interferes with the cleavage of viral polyproteins, preventing the formation of functional viral particles. | ||||||
Atazanavir | 198904-31-3 | sc-207305 | 5 mg | $286.00 | 7 | |
Atazanavir is another protease inhibitor that blocks the cleavage of viral polyproteins, inhibiting the maturation of new viral particles. | ||||||