T2R9 Inhibitors

Chemical inhibitors of T2R9 function by directly binding to the receptor sites of this protein, which is a member of the bitter taste receptor family. Denatonium Benzoate is a potent bitterant that can inhibit T2R9 by occupying its taste receptor site more effectively than other bitter substances, thereby preventing their activation of the receptor. Similarly, Quinine serves as a competitive binder to T2R9, blocking the receptor activation by other bitter tastants to which T2R9 is sensitive. Another inhibitor, Parthenolide, can bind to the active sites of T2R9, preventing the receptor activation by other bitter compounds. Colchicine, found in the autumn crocus, can also inhibit T2R9 through receptor binding, which prevents the interaction and activation of T2R9 by other bitter molecules. Amarogentin, with its extreme bitterness, can inhibit T2R9 by high-affinity binding, which in turn blocks the receptor and inhibits its activation.

In addition, Taxifolin, a flavonoid with a bitter taste profile, can inhibit T2R9 by competing with other ligands for the receptor, preventing receptor activation. Salicin, found in willow bark, can inhibit T2R9 by directly binding to the receptor sites, blocking the activation by other bitter tastants. Propylthiouracil, known for its bitter taste, and Naringin, another bitter flavonoid, both can inhibit T2R9 by binding directly to the receptor's active sites. Sucrose Octaacetate, recognized for its bitter taste, can inhibit T2R9 by occupying the receptor site, preventing the binding of other bitter tastants. Phenylthiocarbamide, a compound that is variably bitter to different individuals, can inhibit T2R9 by receptor binding, which blocks activation by other substances. Lastly, Absinthin, a bitter compound from wormwood, inhibits T2R9 by competitive binding to the receptor, preventing activation by other bitter compounds. These various chemicals provide multiple avenues to inhibit T2R9 by direct interaction with the receptor, effectively blocking the binding and subsequent signaling that would normally be triggered by bitter tastants.