T2R60 Activators

T2R60, a member of the bitter taste receptor family, responds to a wide range of bitter compounds. Each of these compounds, in their interaction with T2R60, triggers the G-protein-coupled receptor signaling pathway, leading to an increase in intracellular calcium levels. Compounds such as quinine, denatonium, and chloroquine are renowned for their bitter taste and their ability to activate T2R60. Alkaloids like yohimbine and theobromine also stimulate the receptor, increasing its functional activity. This activation is not limited to naturally occurring compounds; synthesized molecules like denatonium also exhibit this ability.

Other chemicals, including berberine, caffeine, colchicine, gentamicin, salicin, amygdalin, and parthenolide, have demonstrated the potential to interact with T2R60, initiating the G-protein signaling pathway and enhancing intracellular calcium levels. The bitter taste associated with these compounds arises from their activation of T2R60, among other bitter taste receptors. It is noteworthy that, despite their structural diversity, all these compounds activate T2R60 in a similar manner, underscoring the receptor's adaptability and its significant role in detecting a wide range of bitter compounds.