Syne-2 Activators
The class of chemicals known as Syne-2 activators, while not directly targeting Syne-2, play a significant role in modulating the cellular environment and pathways that indirectly influence Syne-2 activity. These activators encompass a range of compounds that target various aspects of cellular structure and signaling, particularly focusing on the dynamics of the cytoskeleton and nuclear envelope.
The first paragraph of the detailed description of this chemical class focuses on their mechanisms of action. Compounds like Jasplakinolide and Cytochalasin D primarily target the actin cytoskeleton, either stabilizing or inhibiting actin filament formation, respectively. This alteration in actin dynamics can indirectly impact Syne-2, which is involved in linking the nuclear envelope to the actin cytoskeleton. Other compounds, such as Y-27632 and ML-7, function by inhibiting enzymes like ROCK and MLCK, which are crucial in regulating cytoskeletal dynamics. By modulating these enzymes, these chemicals can influence the physical properties of cells, potentially affecting the functionality of Syne-2. Similarly, Blebbistatin and Taxol target myosin II and microtubules, respectively, further illustrating the diversity in targeting strategies within this class.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
A cyclodepsipeptide that stabilizes actin filaments and can indirectly affect Syne-2 by altering the actin cytoskeleton dynamics. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
An actin polymerization inhibitor, potentially influencing Syne-2 activity by disrupting actin filament formation. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
An inhibitor of myosin light chain kinase (MLCK), potentially affecting Syne-2 through alterations in actin-myosin dynamics. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
An inhibitor of myosin II ATPase activity, affecting cellular contractility and thus possibly influencing Syne-2. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
A microtubule stabilizer, it can indirectly influence Syne-2 by altering the balance between microtubules and actin filaments. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
A microtubule depolymerizing agent, potentially affecting Syne-2 through alterations in cellular structural dynamics. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An adenylyl cyclase activator, it can indirectly affect Syne-2 by modulating cAMP levels and downstream signaling pathways. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
An inhibitor of the N-WASP, indirectly influencing Syne-2 through changes in actin dynamics. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
A toxin that binds to actin monomers, indirectly affecting Syne-2 by disrupting actin polymerization. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor, it can influence numerous pathways that may indirectly modulate Syne-2 activity. | ||||||