SWAP Inhibitors
SWAP inhibitors are a class of chemical compounds that specifically target and inhibit the function of the SWAP (Suppressor-of-White-APricot) protein, which is involved in RNA splicing regulation. SWAP, also known as SWAP70, plays a critical role in the regulation of mRNA processing, a fundamental process for generating mature mRNA from pre-mRNA through the removal of introns and the joining of exons. This protein is part of the spliceosome complex, which is responsible for ensuring accurate and efficient splicing. By participating in the modulation of splice site selection, SWAP impacts the diversity of proteins that can be produced from a single gene. Inhibitors of SWAP work by disrupting its function within the spliceosome, interfering with the splicing machinery and potentially altering the outcome of mRNA maturation.
The chemical structure and mechanism of action of SWAP inhibitors vary depending on how they target the protein. Some inhibitors may bind to the active domains of SWAP, preventing its interaction with other spliceosomal components and thus halting its role in RNA splicing. Others may induce conformational changes in SWAP that impair its ability to regulate splice site recognition. Inhibiting SWAP can lead to changes in the splicing pattern of pre-mRNA, which may result in the production of alternative or defective mRNA transcripts. This disruption has downstream effects on gene expression and protein synthesis, revealing the critical role that SWAP plays in post-transcriptional gene regulation. Studying SWAP inhibitors provides valuable insights into the mechanisms of RNA splicing and highlights the importance of splicing factors like SWAP in maintaining cellular homeostasis through proper RNA processing and regulation of protein diversity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
Mitoxantrone, an anthracenedione antineoplastic agent, inhibits topoisomerase II, an enzyme vital for DNA replication and repair. SWAP, involved in RNA processing and splicing, relies on DNA transcription. Inhibition of topoisomerase II by Mitoxantrone can result in decreased transcription of genes including those required for SWAP function, thereby indirectly inhibiting SWAP activity by limiting its RNA substrate. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide is a chemotherapeutic agent that targets topoisomerase II. By stabilizing the DNA-topoisomerase II complex, it inhibits the ligation step of the DNA breakage re-ligation process that topoisomerase II facilitates. This action can reduce transcriptional activity necessary for SWAP function, thus indirectly inhibiting SWAP by reducing the availability of pre-mRNA splicing substrates. | ||||||
Teniposide | 29767-20-2 | sc-204910 sc-204910A | 25 mg 100 mg | $72.00 $230.00 | 6 | |
Teniposide acts similarly to Etoposide, as a topoisomerase II poison. It stabilizes the DNA-topoisomerase complex, preventing DNA relegation and leading to DNA breaks. By inhibiting proper DNA replication and transcription processes, Teniposide can indirectly inhibit SWAP by curtailing the production of RNA substrates that are necessary for SWAP's RNA splicing activity. | ||||||
Amsacrine hydrochloride | 54301-15-4 | sc-214540 | 10 mg | $232.00 | ||
Amsacrine is an acridine derivative that also inhibits topoisomerase II by intercalating into DNA and stabilizing the DNA-topoisomerase II complex. This disrupts DNA synthesis and function, which can indirectly lead to reduced transcription of genes and subsequent RNA substrates that are essential for SWAP's splicing activity. | ||||||
ICRF-193 | 21416-68-2 | sc-200889 sc-200889A | 1 mg 5 mg | $330.00 $898.00 | 7 | |
ICRF-193 is a bisdioxopiperazine compound that inhibits topoisomerase II by binding to the enzyme and preventing it from altering DNA topology, which inhibits DNA replication and transcription. This inhibition can indirectly reduce the RNA substrate pool required for SWAP's splicing function. | ||||||
Novobiocin | 303-81-1 | sc-362034 sc-362034A | 5 mg 25 mg | $96.00 $355.00 | ||
Novobiocin is a coumarin antibiotic that inhibits DNA gyrase, a type of topoisomerase II found in bacteria, and can also affect eukaryotic topoisomerase II. By inhibiting this enzyme, Novobiocin can indirectly lead to a decrease in RNA synthesis, impacting the substrate availability for SWAP's RNA splicing activity. | ||||||
(+)-Irinotecan | 97682-44-5 | sc-269253 | 10 mg | $61.00 | 1 | |
Irinotecan is a semisynthetic derivative of camptothecin that inhibits topoisomerase I. It is used to induce S-phase cell cycle arrest. Irinotecan can indirectly inhibit SWAP through its action on topoisomerase I, leading to reduced transcription and availability of RNA for SWAP-mediated splicing. | ||||||
Topotecan | 123948-87-8 | sc-338718 | 100 mg | $571.00 | ||
Topotecan, another topoisomerase I inhibitor, binds to the topoisomerase I-DNA complex and prevents DNA relegation. This action can lead to a decrease in RNA synthesis, indirectly inhibiting the SWAP protein by reducing the pool of RNA that SWAP modifies. | ||||||
β-Lapachone | 4707-32-8 | sc-200875 sc-200875A | 5 mg 25 mg | $110.00 $450.00 | 8 | |
Beta-Lapachone is a natural quinone compound that has been found to indirectly inhibit DNA topoisomerases and affect DNA repair mechanisms. This can result in decreased transcription levels, which can subsequently reduce SWAP's functional activity due to a lower availability of RNA substrates for splicing. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $142.00 $558.00 | 4 | |
Ellipticine is a natural product that intercalates with DNA and is known to inhibit topoisomerase II. Its intercalation can inhibit DNA transcription, which would indirectly inhibit SWAP | ||||||