SUMO-3 Activators
Common SUMO-3 Activators include, but are not limited to Parthenolide CAS 20554-84-1, MG-132 [Z-Leu- Leu-Leu-CHO] CAS 133407-82-6, Arsenic(III) oxide CAS 1327-53-3, Hydrogen Peroxide CAS 7722-84-1 and Tunicamycin CAS 11089-65-9.
The Small Ubiquitin-like Modifier (SUMO) proteins, including SUMO-3, play a critical role in the post-translational modification of proteins, affecting protein stability, localization, and function. SUMOylation can be influenced by various cellular stresses or signaling pathways. SUMO-3 Activators belong to a class of compounds that are involved in the regulation of post-translational modifications known as SUMOylation. SUMO, or Small Ubiquitin-like Modifier, is a protein that plays a crucial role in modifying other proteins within cells. This modification process, known as SUMOylation, involves the covalent attachment of SUMO proteins to target proteins, altering their functions and interactions. SUMOylation is essential for various cellular processes, including gene expression, DNA repair, protein stability, and cellular localization. SUMO-3 is one of the isoforms of SUMO proteins found in humans, and activators within this chemical class are designed to modulate or enhance the SUMOylation process, particularly that of SUMO-3.
SUMOylation is a dynamic process regulated by a balance between enzymes that add SUMO molecules (SUMO ligases) and enzymes that remove them (SUMO proteases). SUMO-3 activators likely influence this equilibrium, either by promoting the attachment of SUMO-3 to target proteins or by preventing its removal. This chemical class's compounds could serve as valuable tools in research to better understand the intricate regulatory networks governed by SUMOylation. By modulating SUMO-3 activity, researchers can gain insights into the role of specific target proteins and their functions within the cell. Additionally, these activators might have applications in the development of experimental techniques and assays aimed at investigating the consequences of altered SUMOylation patterns, shedding light on various cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
Increases protein stability and interaction of SUMO E2 conjugating enzyme Ubc9, enhancing sumoylation. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Inhibits desumoylating enzymes SENP1/2, leading to accumulation of sumoylated proteins. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that prevents degradation of sumoylated proteins, increasing SUMO-3 levels. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Induces oxidative stress and has been shown to stimulate global SUMOylation, potentially increasing SUMO-3 expression as part of the cellular response. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Causes oxidative stress, which can affect the SUMOylation machinery and potentially lead to increased SUMO-3 expression. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Induces ER stress, which can affect the SUMOylation machinery and potentially lead to changes in SUMO-3 levels. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Activates AMPK, which might have downstream effects on SUMOylation processes and SUMO-3 expression. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Induces ER stress and might influence SUMOylation processes, including SUMO-3 expression. | ||||||