SUHW4 Activators
SUHW4 activators encompass a variety of chemical compounds that indirectly facilitate the functional activity of SUHW4 through their influence on cellular signaling pathways and transcriptional regulation mechanisms. Forskolin, by increasing cAMP levels and consequently activating PKA, primes the phosphorylation landscape to potentially favor SUHW4's role in gene expression modulation. Similarly, PMA activates PKC, which may enhance SUHW4's activity through phosphorylation or alterations in the cellular milieu. Sphingosine-1-phosphate can initiate signaling cascades that enhance the activity of nuclear receptors, potentially including SUHW4, while Ionomycin, by increasing intracellular calcium, activates calcium-dependent pathways that could augment SUHW4's transcriptional regulation functions. The cAMP analog 8-Bromo-cAMP also activates PKA, implying a similar potential for enhancing SUHW4 activity, and Oligomycin, by inhibiting mitochondrial ATP synthase, indirectly activates AMPK, which may modulate SUHW4 activity in response to the cellular energy state.
Further, activators such as EGCG can influence various signaling pathways and affect SUHW4's interaction with other molecular players or its phosphorylation status. LY294002, by inhibiting PI3K, can alter the AKT signaling pathway, impacting the transcriptional context in which SUHW4 operates. Rapamycin, through mTOR inhibition, affects cellular growth signals,potentially leading to enhanced SUHW4 activity through altered gene expression networks. SB203580 and U0126, which inhibit p38 MAPK and MEK1/2 respectively, could shift the balance of intracellular signaling to pathways that favor the activation of SUHW4. Furthermore, Trichostatin A, by inhibiting HDACs, could increase chromatin accessibility for SUHW4, enhancing its capacity to regulate gene expression. Collectively, these compounds contribute to the creation of a cellular environment conducive to the activation and potentiation of SUHW4's role in the regulation of gene expression, without directly increasing its expression or requiring direct activation of the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can potentially phosphorylate SUHW4 or its associated regulatory proteins, thereby enhancing SUHW4's functional activity in gene expression regulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is known to activate protein kinase C (PKC). Activation of PKC can lead to downstream effects that enhance the activity of DNA-binding proteins like SUHW4 through phosphorylation or changes in the cellular environment that favor SUHW4's activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
This lipid signaling molecule can activate sphingosine-1-phosphate receptors, leading to downstream effects that may include the enhancement of nuclear receptor activity, potentially influencing SUHW4's function in transcriptional regulation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
A calcium ionophore that increases intracellular calcium levels, which could activate calcium-dependent signaling pathways. This can indirectly enhance the activity of DNA-binding proteins such as SUHW4 by influencing their phosphorylation state or interaction with co-regulators. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
A cAMP analog that activates PKA, potentially leading to enhanced activity of SUHW4 by affecting its phosphorylation state and interaction with transcriptional machinery. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
An inhibitor of mitochondrial ATP synthase, leading to increased intracellular AMP levels, which can activate AMPK. AMPK activation may influence SUHW4 activity through changes in cellular energy balance and signaling pathways associated with gene regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A polyphenol that can modulate multiple signaling pathways, potentially affecting transcription factors like SUHW4 by altering their interaction network or phosphorylation status. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that can alter the PI3K/AKT signaling pathway, possibly leading to the modulation of transcription factor activity, including that of SUHW4, by affecting the cellular context in which SUHW4 operates. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, which can affect the cellular growth signaling environment, potentially leading to an enhancement of SUHW4 activity by influencing gene expression patterns and transcriptional regulatory networks. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor that may shift the signaling balance in the cell, potentially favoring pathways that activate or enhance the functional activity of transcription factors like SUHW4. | ||||||