Statherin Inhibitors
Statherin is primarily recognized for its role in the oral environment, particularly in saliva, where it plays an essential function in mineral homeostasis and dental enamel remineralization. Statherin Inhibitors would encompass molecules or compounds that have an ability to specifically inhibit the expression or function of statherin without significantly affecting other proteins.
Given statherin's role in maintaining calcium and phosphate ion homeostasis in saliva, compounds in this class would presumably alter this balance, possibly impacting processes like spontaneous precipitation and crystal growth of calcium phosphate salts. Additionally, since statherin also serves as a boundary lubricant in the oral cavity and has affinity for hydroxyapatite, effective inhibitors might also influence these interactions.
In determining Statherin Inhibitors, rigorous chemical and biological assays would be essential to screen and validate compounds for specificity and efficacy. Molecular modeling could also aid in understanding the statherin protein structure and identifying binding sites or areas of interaction. It would be crucial for these inhibitors to have a targeted effect on statherin without significant off-target interactions to ensure specificity. As with any chemical class, understanding the mechanism of action, and broader biological implications would be of utmost importance.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D is known to intercalate DNA, thereby inhibiting RNA synthesis. Its inhibition of RNA polymerase can reduce protein expression,. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by disrupting the translocation step in translation, causing early chain termination. This could result in reduced Statherin expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an inhibitor of the protein kinase mTOR, which plays a key role in protein synthesis. By inhibiting mTOR, Rapamycin can reduce overall protein expression including Statherin. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Mycophenolic acid inhibits inosine monophosphate dehydrogenase, leading to a decrease in guanine nucleotide synthesis. This may reduce RNA and protein synthesis, potentially affecting Statherin. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a bacterial antibiotic that inhibits protein synthesis in eukaryotes by blocking peptide bond formation. This can lead to reduced protein expression, including Statherin. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin is a potent inhibitor of RNA polymerase II, which is responsible for mRNA synthesis. Inhibiting this enzyme could reduce protein expression, potentially impacting Statherin levels. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin binds to heat shock protein 90 (Hsp90) and disrupts its function. Hsp90 plays a role in the proper folding of proteins, and its inhibition can affect the expression and function of its client proteins. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of phosphoinositide 3-kinases (PI3K). PI3K plays a role in various cellular processes, including protein synthesis, and its inhibition can affect protein expression levels. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C is an alkylating agent that cross-links DNA, inhibiting DNA synthesis and function. This can indirectly reduce RNA synthesis and subsequent protein expression, potentially affecting Statherin. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits the DNA enzyme topoisomerase I, preventing DNA from uncoiling and affecting DNA replication and transcription. This can reduce overall protein synthesis, possibly impacting Statherin. | ||||||