ST5 Inhibitors
Chemical inhibitors of ST5 target various signaling pathways to disrupt the protein's function within cellular processes such as cytoskeletal organization and cell migration. Wortmannin and LY294002, both inhibitors of phosphoinositide 3-kinases (PI3K), can prevent the phosphorylation of downstream targets engaged in ST5 signaling cascades. This inhibition can reduce the activity of proteins that interact with ST5, leading to its functional inhibition. Similarly, PD98059 and U0126, which are inhibitors of MEK, a component of the MAPK/ERK pathway, can impair the signaling necessary for ST5's role in cellular responses to external signals. Inhibition of MEK by these chemicals can thus affect ST5's contribution to processes like cell migration and adhesion.
Compounds like SP600125 and SB203580 modulate the stress and inflammatory response pathways by inhibiting JNK and p38 MAP kinase, respectively. These kinases are involved in signaling cascades that ST5 may influence; thus, their inhibition can lead to a functional disruption of ST5. Additionally, Src family tyrosine kinases, which play a role in cytoskeletal dynamics, are targeted by PP2 and Dasatinib. Inhibition of these kinases can consequently disrupt ST5-associated functions, primarily related to the cytoskeletal changes necessary for cell morphology and motility. Y-27632 and ML7 target the Rho-associated protein kinase (ROCK) and myosin light chain kinase (MLCK), respectively, affecting actin-myosin interactions crucial for ST5-mediated cellular processes. Lastly, inhibitors like BIM-1 and Go6983, which inhibit protein kinase C (PKC), can alter signal transduction pathways involving cell growth and differentiation, leading to the functional inhibition of ST5 by disrupting the signaling pathways it is part of.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are upstream regulators in pathways that could impact the activity of ST5 by altering the cytoskeletal organization and cellular migration. Inhibition of PI3K can lead to reduced activity of downstream effectors that are crucial for ST5-mediated signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another inhibitor of PI3K, similar to Wortmannin, and it can inhibit the phosphorylation of downstream targets that are likely involved in the signaling cascades that ST5 participates in. By inhibiting PI3K, LY294002 can reduce the activity of proteins that interact with ST5, thereby functionally inhibiting ST5. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. As ST5 is associated with cell adhesion and migration, inhibition of MEK can disrupt these pathways, potentially leading to a functional inhibition of ST5 through reduced cellular response to extracellular signals. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is involved in stress-activated protein kinase signaling pathways. Inhibition of JNK can alter the cellular responses to stress and cytokines, which may be crucial for ST5's role in cellular signaling and thus indirectly inhibit ST5 function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase, involved in inflammatory cytokine signaling. Given that ST5 is implicated in cellular response mechanisms, inhibiting p38 MAP kinase can disrupt signaling pathways that ST5 influences, leading to its functional inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, which is another component of the MAPK/ERK pathway. By preventing MEK activation, U0126 can impair the signaling required for the proper functioning of ST5, particularly in pathways related to cell migration and adhesion. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. Src kinases can modulate cytoskeletal dynamics, and by inhibiting these kinases, PP2 can disrupt functions associated with ST5, particularly in the context of cell morphology and motility. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor with activity against Src family kinases. By inhibiting these kinases, Dasatinib can impair signaling cascades that involve ST5, especially those related to cell adhesion and migration. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK), and disruption of ROCK activity can lead to changes in actin cytoskeleton organization and cell motility. Since ST5 is involved in cytoskeletal rearrangement, inhibition of ROCK by Y-27632 can functionally inhibit ST5. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML7 is an inhibitor of myosin light chain kinase (MLCK), and by inhibiting MLCK, ML7 can affect actin-myosin contraction, which is important for cellular processes that ST5 is likely to influence, such as cell migration and adhesion. | ||||||