SRMS Activators
SRMS activators are a category of chemical compounds that have been identified for their ability to modulate the activity of the Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites (SRMS). As a non-receptor tyrosine kinase, SRMS is part of a larger family of proteins known for their roles in various cellular processes, including signal transduction pathways that govern cell division, survival, differentiation, and migration. The activation of SRMS by these activators can occur through direct interaction with the kinase domain of the protein, leading to a conformational change that enhances its catalytic activity. Alternatively, indirect mechanisms may involve the modulation of upstream regulators or downstream effectors that, in turn, influence SRMS activity.
At the molecular level, activators may interact with the ATP-binding site of SRMS, mimicking the effects of phosphorylation, or they might stabilize active conformations of the enzyme. The precise mechanism of action for each SRMS activator can vary, with some promoting the association of SRMS with specific substrates or scaffold proteins that are essential for its activity. The activation of SRMS by these compounds often leads to an increase in the phosphorylation of tyrosine residues on a variety of downstream substrates, impacting signaling networks within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Src kinase family inhibitor. SRMS is a member of the Src family kinases, and while Dasatinib is an inhibitor, it may paradoxically induce activation of SRMS via compensatory feedback mechanisms. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is also a Src kinase family inhibitor. Similarly to Dasatinib, PP2 could potentially induce activation of SRMS through compensatory mechanisms after inhibition of other Src family kinases. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator. Activation of JNK can stimulate the translocation of certain nuclear factors, which can influence the expression or activity of SRMS if it's a target of these factors. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor which can indirectly activate the AMPK pathway. If SRMS is involved in the AMPK pathway or is regulated by it, this can potentially enhance its activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an AMP-activated protein kinase (AMPK) activator. If SRMS is involved in the AMPK pathway or is regulated by it, AICAR can potentially enhance its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor which can indirectly activate autophagy. If SRMS is involved in autophagy or is regulated by it, this can potentially enhance its activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a SIRT1 activator. If SRMS is involved in the SIRT1 pathway or regulated by it, Resveratrol can potentially enhance its activity. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin is an AMPK activator. If SRMS is involved in the AMPK pathway or is regulated by it, Metformin can potentially enhance its activity. | ||||||
SB202190 hydrochloride | 350228-36-3 | sc-222294 sc-222294A | 1 mg 5 mg | $128.00 $495.00 | 13 | |
SB202190 is a p38 MAPK inhibitor which can indirectly activate the JNK pathway. If SRMS is involved in the JNK pathway or regulated by it, this can potentially enhance its activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is an NF-kB inhibitor which can indirectly activate the JNK pathway. If SRMS is involved in the JNK pathway or is regulated by it, Curcumin can potentially enhance its activity. | ||||||