SQSTM1-L1 inhibitors are a class of chemical compounds designed to specifically target and inhibit the function of the SQSTM1-L1 protein, a variant of the sequestosome 1 (SQSTM1) family involved in cellular processes such as autophagy, signaling, and protein degradation. SQSTM1-L1 functions as a scaffold protein, facilitating the interaction between ubiquitinated proteins and the autophagic machinery, thus playing a critical role in the selective degradation of misfolded proteins and damaged organelles. It also serves as a signaling mediator in pathways related to cellular stress and the maintenance of protein homeostasis. Inhibitors of SQSTM1-L1 block its ability to interact with other proteins, preventing its involvement in the degradation processes and altering how cells manage protein turnover and stress responses.
The study of SQSTM1-L1 inhibitors provides valuable insights into the regulation of autophagy and protein degradation. By inhibiting SQSTM1-L1, researchers can explore how this protein contributes to the clearance of damaged proteins and organelles, as well as its role in broader cellular maintenance mechanisms. The inhibition of SQSTM1-L1 offers a window into how disruptions in protein degradation impact cellular homeostasis, potentially affecting processes such as oxidative stress response, inflammation, and signal transduction. These inhibitors help delineate the specific molecular interactions mediated by SQSTM1-L1, allowing for a better understanding of its contribution to cellular quality control mechanisms. Research on SQSTM1-L1 inhibitors also aids in uncovering the intricacies of protein ubiquitination and its connections to autophagy, providing critical information on how cells maintain balance in the face of environmental and internal challenges.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may downregulate NF-κB signaling, which can decrease SQSTM1 expression as it is a downstream target of this transcription factor. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to modulate autophagy and could reduce SQSTM1 levels by altering signaling pathways that control its gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG may affect the expression of autophagy-related genes, potentially lowering SQSTM1 levels through transcriptional regulation. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $150.00 $920.00 | 5 | |
Sunitinib might influence autophagy flux and thereby modulate the stability or translation of SQSTM1 mRNA indirectly. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a kinase inhibitor that could disrupt signaling pathways responsible for SQSTM1 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, could impact the pathways regulating SQSTM1 expression by modulating upstream signals. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a major regulator of autophagy, potentially decreasing SQSTM1 expression as part of feedback regulation. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
3-methyladenine, an autophagy inhibitor, might reduce SQSTM1 expression by interfering with upstream autophagic signaling. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
Spautin-1 is known to promote the degradation of autophagy-related proteins and could indirectly lead to reduced SQSTM1 expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine impairs autophagosome fusion with lysosomes, potentially causing a feedback decrease in SQSTM1 expression. | ||||||