SPATA7 Inhibitors
SPATA7 inhibitors encompass a variety of compounds that affect different signaling pathways and cellular processes, ultimately leading to the inhibition of SPATA7 activity, particularly within the context of spermatogenesis. Kinase inhibitors targeting essential phosphorylation events necessary for SPATA7 activation have a profound effect on its activity by preventing post-translational modifications critical for its function. Additionally, compounds that modulate metabolic pathways, such as selective PPARγ modulators, have an indirect impact on SPATA7 by influencing the energetic and metabolic status of spermatogenic cells, which is essential for proper spermatogenesis. Inhibition of glucose uptake disrupts the energy balance, further contributing to decreased SPATA7 activity, while mTOR signaling inhibitors like rapamycin can impede pathways that regulate cell growth and proliferation, processes in which SPATA7 is intricately involved.
Similarly, the disruption of PI3K/Akt signaling through specific pathway inhibitors alters cellular survival signals, indirectly influencing SPATA7 functionality. Inhibitors of the Hedgehog pathway and BMP signaling also contribute to the indirect inhibition of SPATA7 by affecting the differentiation and proliferation of cells within the testis. Moreover, allosteric inhibitors of tyrosine kinases and Aurora kinases play a rolein modulating cell division and chromosomal segregation, indirectly affecting SPATA7's involvement in these processes. The inhibition of protein folding mechanisms via Hsp90 inhibitors can lead to the destabilization and degradation of proteins that interact with or regulate SPATA7, thereby diminishing its activity. Additionally, compounds that interfere with the microtubule network within cells have the potential to disrupt the structural integrity and division of spermatogenic cells, which could indirectly lead to reduced SPATA7 action.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
This kinase inhibitor effectively blocks protein kinases that are necessary for the phosphorylation of SPATA7, which is a prerequisite for its functional activity in spermatogenesis. The inhibition of these kinases leads to decreased SPATA7 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
This mTOR inhibitor disrupts the mTOR signaling pathway, which is involved in the regulation of cell growth and proliferation. As SPATA7 is associated with spermatogenesis, inhibiting this pathway can lead to reduced SPATA7 activity. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
This glucose transporter 1 (GLUT1) inhibitor decreases glucose uptake in cells, potentially affecting the energy status and thereby indirectly inhibiting energy-dependent processes, including those in which SPATA7 is involved. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
This compound inhibits MEK, which is part of the MAPK/ERK pathway. Disruption of this pathway can lead to altered signaling processes in spermatogenic cells, thereby indirectly inhibiting SPATA7 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
As a PI3K inhibitor, it impedes the PI3K/Akt signaling pathway, which plays a role in cell survival and metabolism. This could indirectly affect SPATA7's role in spermatogenesis by altering cellular energy and survival signals. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
This inhibitor of the Hedgehog signaling pathway may alter cellular differentiation and proliferation processes in the testis, indirectly impacting SPATA7's function in spermatogenesis. | ||||||
Bcr-abl Inhibitor | 778270-11-4 | sc-203836 | 5 mg | $149.00 | 1 | |
This allosteric Bcr-Abl inhibitor disrupts tyrosine kinase signaling, which is crucial for various cellular processes. By altering signaling cascades, it could indirectly affect SPATA7's role in the development of sperm. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
This inhibitor of BMP signaling can impact cellular differentiation pathways in the testis. Since SPATA7 is associated with spermatogenesis, disruption of these pathways could indirectly lead to decreased SPATA7 activity. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
This Hsp90 inhibitor disrupts protein folding processes and can lead to the degradation of client proteins involved in spermatogenesis, potentially affecting SPATA7's role in this process. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $70.00 $282.00 | 6 | |
This metabolite of estradiol can interfere with microtubule function, which is critical for cell division and structural maintenance in spermatogenic cells. This disruption could indirectly reduce SPATA7 activity. | ||||||