SPATA22 Activators
SPATA22, as a vital cog in the DNA repair machinery, can interact with and be modulated by various chemicals that target the DNA structure or DNA processing enzymes. Cisplatin, Bleomycin, MMS, Etoposide, Camptothecin, and Mitomycin C, for instance, directly interact with DNA. These agents cause different types of DNA lesions – from crosslinks to strand breaks – which in turn necessitate the involvement of repair proteins, among which SPATA22 is significant.
Furthermore, the panorama of DNA replication and repair is intricate, with various agents playing roles in inducing stress or inhibiting crucial enzymes. Hydroxyurea and Aphidicolin, for instance, stall replication forks, which can then call upon repair proteins like SPATA22. Nocodazole, by disrupting microtubule dynamics, introduces an indirect mechanism to affect related processes. On the enzyme regulation front, Olaparib, a PARP, and the ATR VE-821, both affect pivotal enzymes in DNA repair pathways. The modification of these enzyme activities creates a ripple effect across the repair landscape, possibly modulating the function or levels of SPATA22.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
DNA damaging agent that induces DNA repair mechanisms, which can involve proteins like SPATA22. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Inhibits ribonucleotide reductase leading to stalled replication forks, thereby activating DNA repair processes. | ||||||
Bleomycin Sulfate | 9041-93-4 | sc-200134 sc-200134A sc-200134B sc-200134C | 10 mg 50 mg 100 mg 500 mg | $206.00 $612.00 $1020.00 $2856.00 | 38 | |
Causes DNA strand breaks which can induce the DNA repair machinery, including SPATA22 involvement. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Inhibits DNA polymerase, inducing DNA replication stress and the subsequent activation of DNA repair mechanisms. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $55.00 $130.00 | 2 | |
Alkylating agent that can cause DNA damage, inducing DNA repair pathways that involve SPATA22. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Induces DNA double-strand breaks leading to activation of the DNA repair machinery. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Topoisomerase I inhibitor causing DNA breaks and thus activation of DNA repair processes. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Misincorporates into DNA leading to DNA damage and subsequent activation of repair mechanisms. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Disrupts microtubule dynamics; can affect processes related to DNA repair. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
Inhibits ATR, a key DNA damage response kinase. This can modulate DNA repair pathways possibly influencing SPATA22. | ||||||