Sodium Channel Modulators
Items 21 to 30 of 74 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Disopyramide phosphate salt | 22059-60-5 | sc-252757 | 1 g | $220.00 | ||
Disopyramide phosphate salt acts as a sodium channel modulator by selectively binding to the channel's voltage-sensing domains, altering the conformational state of the channel. This interaction results in a delayed recovery from inactivation, impacting the overall excitability of neuronal and cardiac tissues. Its unique electrostatic properties facilitate specific ionic interactions, enhancing its efficacy in modulating channel activity under varying physiological conditions. | ||||||
Halofantrine hydrochloride | 36167-63-2 | sc-255195 | 10 mg | $120.00 | ||
Halofantrine hydrochloride functions as a sodium channel modulator by engaging with the channel's hydrophobic regions, leading to a stabilization of the inactivated state. This interaction disrupts the normal ion flow, effectively altering the kinetics of channel activation and inactivation. Its distinct lipophilic characteristics promote enhanced membrane permeability, allowing for a more pronounced effect on channel dynamics, particularly under altered ionic environments. | ||||||
Bupivacaine Free Base | 38396-39-3 | sc-204657 sc-204657A sc-204657B sc-204657C | 1 g 5 g 25 g 100 g | $226.00 $389.00 $1485.00 $4080.00 | 2 | |
Bupivacaine Free Base acts as a sodium channel modulator by selectively binding to the channel's voltage-sensing domains, which influences the conformational changes necessary for channel gating. This binding alters the kinetics of sodium ion conduction, resulting in prolonged channel inactivation. Its unique hydrophobic interactions enhance its affinity for lipid membranes, facilitating deeper penetration and more effective modulation of channel activity in diverse ionic conditions. | ||||||
Flecainide | 54143-55-4 | sc-219833 | 100 mg | $372.00 | ||
Flecainide functions as a sodium channel modulator by stabilizing the inactivated state of the channel, effectively reducing the frequency of channel opening. Its unique structure allows for specific interactions with the channel's inner pore, influencing ion flow dynamics. The compound exhibits distinct reaction kinetics, characterized by a rapid onset of action and a prolonged duration of effect, which is attributed to its lipophilic nature that enhances membrane partitioning and channel affinity. | ||||||
Aconitine | 302-27-2 | sc-202441 sc-202441A sc-202441B sc-202441C sc-202441D | 25 mg 50 mg 100 mg 250 mg 500 mg | $300.00 $450.00 $650.00 $1252.00 $2050.00 | ||
Aconitine acts as a sodium channel modulator by promoting persistent activation of the channel, leading to prolonged depolarization of excitable membranes. Its unique alkaloid structure facilitates strong binding to the channel's voltage-sensing domains, altering gating kinetics. This interaction results in a distinctive pattern of ion conductance, characterized by a slow recovery from inactivation, which can significantly impact cellular excitability and signal propagation. | ||||||
Mepivacaine hydrochloride | 1722-62-9 | sc-252996 | 1 g | $140.00 | ||
Mepivacaine hydrochloride functions as a sodium channel modulator by selectively inhibiting the channel's opening, thereby reducing ion flow across membranes. Its unique amide structure enhances binding affinity to the channel's inactivation gate, leading to a rapid onset of action. This modulation alters the kinetics of channel recovery, resulting in a distinctive profile of excitability suppression. The compound's hydrophilic nature influences its interaction dynamics with lipid membranes, affecting overall channel behavior. | ||||||
Mexiletine hydrochloride (≥98%) | 5370-01-4 | sc-253048 | 25 g | $82.00 | ||
Mexiletine hydrochloride acts as a sodium channel modulator by stabilizing the inactivated state of the channel, effectively prolonging its closure. This compound exhibits a unique ability to alter the voltage-dependent activation and inactivation kinetics, leading to a distinct modulation of neuronal excitability. Its specific interactions with the channel's binding sites enhance selectivity, while its solubility characteristics facilitate effective membrane penetration, influencing overall channel dynamics. | ||||||
SDZ-201106 (+) | 97730-95-5 (racemic) | sc-222302 | 5 mg | $59.00 | ||
SDZ-201106 (+) functions as a sodium channel modulator by selectively binding to the channel's voltage-sensing domains, thereby influencing gating mechanisms. This compound exhibits a unique capacity to shift the activation threshold, altering the channel's response to depolarization. Its kinetic profile reveals a rapid onset of action, with a notable impact on recovery from inactivation, which can significantly affect neuronal signaling pathways and excitability. | ||||||
BIA 2-093 | 236395-14-5 | sc-252432 | 10 mg | $162.00 | 2 | |
BIA 2-093 acts as a sodium channel modulator through its interaction with specific allosteric sites on the channel protein, leading to alterations in ion permeability. This compound demonstrates a distinctive ability to stabilize the inactivated state of the channel, effectively prolonging the refractory period. Its reaction kinetics indicate a gradual binding process, which influences the channel's overall conductance and impacts cellular excitability dynamics. | ||||||
Veratridine | 71-62-5 | sc-201075B sc-201075 sc-201075C sc-201075A | 5 mg 10 mg 25 mg 50 mg | $80.00 $102.00 $197.00 $372.00 | 3 | |
Veratridine is a potent sodium channel modulator that uniquely binds to the channel's voltage-sensing domains, enhancing sodium ion influx. This compound exhibits a rapid activation profile, significantly altering the channel's gating kinetics. Its interaction promotes a persistent open state, resulting in prolonged depolarization. Additionally, Veratridine's ability to induce conformational changes in the channel structure affects the overall excitability of neuronal and muscle tissues, showcasing its distinct mechanistic role. | ||||||