Halofantrine hydrochloride (CAS 36167-63-2)
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Halofantrine hydrochloride is used in research related to its effects on cell membrane properties in various model systems. It is particularly valuable in studies aimed at understanding the interactions between chemicals and cell membranes, due to its amphiphilic nature. In biophysical research, halofantrine hydrochloride serves as a tool for examining how molecular structures influence the behavior of molecules within lipid bilayers, for cell membrane integrity and function. This compound is also utilized in the study of resistance mechanisms in microorganisms, helping scientists to understand how changes at the molecular level can impact the efficacy of compounds with similar properties. Additionally, halofantrine hydrochloride is employed in electrochemical studies to explore its redox properties and how these properties affect its behavior in biological systems.
Halofantrine hydrochloride (CAS 36167-63-2) References
- Pharmacokinetics of halofantrine in the rat: stereoselectivity and interspecies comparisons. | Brocks, DR. and Toni, JW. 1999. Biopharm Drug Dispos. 20: 165-9. PMID: 10211870
- Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5. | Baune, B., et al. 1999. J Pharm Pharmacol. 51: 419-26. PMID: 10385214
- Stereoselective halofantrine and desbutylhalofantrine disposition in the rat: cardiac and plasma concentrations and plasma protein binding. | Brocks, DR. 2002. Biopharm Drug Dispos. 23: 9-15. PMID: 11891669
- The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels. | Mbai, M., et al. 2002. Cardiovasc Res. 55: 799-805. PMID: 12176129
- Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria. | Krishna, S., et al. 1993. Br J Clin Pharmacol. 36: 585-91. PMID: 12959277
- In vitro activity of halofantrine and its relationship to other standard antimalarial drugs against African isolates and clones of Plasmodium falciparum. | Basco, LK. and Le Bras, J. 1992. Am J Trop Med Hyg. 47: 521-7. PMID: 1443351
- Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80. | Lind, ML., et al. 2008. Eur J Pharm Sci. 35: 211-8. PMID: 18675904
- Effect of bile and lipids on the stereoselective metabolism of halofantrine by rat everted-intestinal sacs. | Patel, JP., et al. 2010. Chirality. 22: 275-83. PMID: 19496124
- Pharmacokinetics of halofantrine in Thai patients with acute uncomplicated falciparum malaria. | Karbwang, J., et al. 1991. Br J Clin Pharmacol. 31: 484-7. PMID: 2049260
- Effect of experimental hyperlipidaemia on the electrocardiographic effects of repeated doses of halofantrine in rats. | Patel, JP. and Brocks, DR. 2010. Br J Pharmacol. 161: 1427-40. PMID: 20698852
- Influence of bile on the absorption of halofantrine from lipid-based formulations. | Holm, R., et al. 2012. Eur J Pharm Biopharm. 81: 281-7. PMID: 22465095
- Mechanistic Oral Absorption Modeling of Halofantrine: Exploring the Role of Intestinal Lymphatic Transport. | Dolton, MJ., et al. 2021. J Pharm Sci. 110: 1427-1430. PMID: 33359312
- Impact of chemoprophylaxis immunisation under halofantrine (CPS-HF) drug cover in Plasmodium yoelii Swiss mice malaria model. | Siddiqui, AJ., et al. 2022. Folia Parasitol (Praha). 69: PMID: 35145048
- Mefloquine effect on disposition of halofantrine in the isolated perfused rat liver. | Leo, KU., et al. 1996. J Pharm Pharmacol. 48: 723-8. PMID: 8866337
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Halofantrine hydrochloride, 10 mg | sc-255195 | 10 mg | $120.00 |