Molecular structure of Flecainide, CAS Number: 54143-55-4
Flecainide (CAS 54143-55-4)
Alternate Names:
N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
Application:
Flecainide is an antiarrhythmic RyR-2 inhibitor
CAS Number:
54143-55-4
Molecular Weight:
414.34
Molecular Formula:
C17H20F6N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Flecainide is a chemical compound with distinct electrophysiological properties that make it a point of interest in cardiovascular research. It has been examined extensively in laboratory applications for its effects on ion channels, particularly sodium channels within cardiac cells. Flecainide influence on ion conductance and membrane potential is a key area of focus, as it provides insights into the fundamental principles of cardiac electrophysiology and excitation-contraction coupling. It also serves as a reference molecule in studies that aim to elucidate the molecular determinants of channel function and the structural basis of ion channel gating.
Flecainide (CAS 54143-55-4) References
- Flecainide-induced myoclonus. | Velasco, SL., et al. 2014. Clin Neuropharmacol. 37: 65-6. PMID: 24614665
- Flecainide intoxication in pediatric patients with supraventricular tachycardia. | Vaquer, G., et al. 2020. Ann Pediatr Cardiol. 13: 264-266. PMID: 32863668
- Is the Debate on the Flecainide Action on the RYR2 in CPVT Closed? | Benitah, JP. and Gómez, AM. 2021. Circ Res. 128: 332-334. PMID: 33539226
- Atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone. | Holmes, AP., et al. 2021. Heart Rhythm. 18: 1212-1220. PMID: 33737232
- Flecainide-induced QRS complex widening correlates with negative inotropy. | Rabêlo Evangelista, AB., et al. 2021. Heart Rhythm. 18: 1416-1422. PMID: 33848647
- Flecainide-induced myalgias and weakness: a rare adverse reaction. | Kumar, D., et al. 2021. BMJ Case Rep. 14: PMID: 33858882
- Flecainide toxicity late after liver transplantation. | Elsaid, O., et al. 2021. Proc (Bayl Univ Med Cent). 34: 378-379. PMID: 33953467
- Mechanisms of flecainide induced negative inotropy: An in silico study. | Yang, PC., et al. 2021. J Mol Cell Cardiol. 158: 26-37. PMID: 34004185
- Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions: A Potential Pro-Arrhythmic Action. | Salvage, SC., et al. 2021. Cells. 10: PMID: 34440870
- Safety and efficacy of flecainide associated with beta-blockers in arrhythmogenic right ventricular cardiomyopathy. | Rolland, T., et al. 2022. Europace. 24: 278-284. PMID: 34459901
- Flecainide poisoning and prolongation of elimination due to alkalinization. | McCabe, DJ., et al. 2022. Am J Emerg Med. 56: 394.e1-394.e4. PMID: 35287973
- A Case Report of Flecainide Toxicity With Review of Literature. | Khatiwada, P., et al. 2022. Cureus. 14: e22261. PMID: 35350525
- Flecainide-Induced Left Bundle Branch Block. | Nuthulaganti, SR., et al. 2022. Cureus. 14: e24385. PMID: 35619832
- Antiarrhythmic effects of flecainide. | Somani, P. 1980. Clin Pharmacol Ther. 27: 464-70. PMID: 7357804
- Electrophysiological effects of a new antiarrhythmic agent, flecainide, on the intact canine heart. | Hodess, AB., et al. 1979. J Cardiovasc Pharmacol. 1: 427-39. PMID: 94620
Inhibitor of:
RyR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Flecainide, 100 mg | sc-219833 | 100 mg | $372.00 |