Date published: 2026-5-26

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SOCS-7 Activators

SOCS-7 Activators is a chemical class known for its ability to modulate the activity and expression of Suppressor of Cytokine Signaling 7 (SOCS-7), a vital component of the SOCS protein family involved in the regulation of intracellular signaling cascades. SOCS-7 plays a pivotal role in fine-tuning cellular responses to cytokines, insulin, and growth hormones, acting as a feedback controller to prevent excessive or prolonged signaling. Chemical compounds falling within the category of SOCS-7 activators are characterized by their potential to influence this regulatory protein, either directly or indirectly, leading to enhanced SOCS-7 expression or activity.

Within this class, one can find a diverse array of chemical agents, each with distinct mechanisms of action. Some SOCS-7 activators operate by triggering the transcription and translation of SOCS-7, thus promoting its expression levels. Others may modulate signaling pathways that intersect with SOCS-7's functions, ultimately leading to the activation of SOCS-7 as a negative feedback mechanism. While the specific modes of action may vary among these activators, the common goal is to bolster SOCS-7's role in regulating cellular responses, thereby contributing to the maintenance of balanced immune responses, insulin sensitivity, and growth hormone signaling. These activators hold great promise in research and experimental settings, where a deeper understanding of SOCS-7 and its associated pathways is crucial for unraveling the intricacies of cellular signaling and its potential implications for various physiological processes.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ruxolitinib

941678-49-5sc-364729
sc-364729A
sc-364729A-CW
5 mg
25 mg
25 mg
$251.00
$500.00
$547.00
16
(1)

JAK inhibitor that directly triggers modulation of the JAK-STAT signaling pathway, potentially activating SOCS-7 by inhibiting key components of the cytokine response cascade.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

PI3K inhibitor that indirectly triggers SOCS-7 by impeding the insulin signaling pathway, a pathway tightly linked to SOCS-7 activation.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

mTOR inhibitor that indirectly activates SOCS-7 through its impact on the mTOR pathway, which plays a role in insulin-related signaling.

1,1-Dimethylbiguanide, Hydrochloride

1115-70-4sc-202000F
sc-202000A
sc-202000B
sc-202000C
sc-202000D
sc-202000E
sc-202000
10 mg
5 g
10 g
50 g
100 g
250 g
1 g
$20.00
$43.00
$63.00
$156.00
$260.00
$510.00
$31.00
37
(1)

Insulin sensitizer that directly enhances insulin sensitivity, potentially activating SOCS-7-mediated regulation of insulin signaling.

Rosiglitazone

122320-73-4sc-202795
sc-202795A
sc-202795C
sc-202795D
sc-202795B
25 mg
100 mg
500 mg
1 g
5 g
$120.00
$326.00
$634.00
$947.00
$1259.00
38
(1)

Thiazolidinedione and insulin sensitizer that may directly or indirectly activate SOCS-7 by improving insulin sensitivity, a process closely related to SOCS-7 function.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$74.00
$243.00
$731.00
$2572.00
$21848.00
53
(3)

Modulator of mRNA stability, which could indirectly activate SOCS-7 expression by impacting the stability of its mRNA transcripts.

Stat3 inhibitor V, stattic

19983-44-9sc-202818
sc-202818A
sc-202818B
sc-202818C
sc-202818D
sc-202818E
sc-202818F
25 mg
100 mg
250 mg
500 mg
1 g
2.5 g
5 g
$130.00
$196.00
$274.00
$512.00
$731.00
$1408.00
$2091.00
114
(3)

STAT inhibitor that directly triggers the inhibition of STAT proteins in signaling pathways, potentially activating SOCS-7 expression and function.

(+)-α-Tocopherol

59-02-9sc-214454
sc-214454A
sc-214454B
sc-214454C
10 g
25 g
100 g
1 kg
$43.00
$62.00
$141.00
$430.00
(1)

Vitamin E with peroxidation-inhibiting properties that indirectly activates SOCS-7 by reducing oxidative stress, a factor that can affect signaling pathways in which SOCS-7 participates.

AICAR

2627-69-2sc-200659
sc-200659A
sc-200659B
50 mg
250 mg
1 g
$65.00
$280.00
$400.00
48
(2)

AMPK activator that directly activates AMPK, an enzyme linked to SOCS-7-related energy regulation pathways.

Rolipram

61413-54-5sc-3563
sc-3563A
5 mg
50 mg
$77.00
$216.00
18
(1)

PDE inhibitor that indirectly activates SOCS-7 by impacting cyclic AMP levels, which are involved in several signaling pathways activated by SOCS proteins.