SOCS-7 Activators is a chemical class known for its ability to modulate the activity and expression of Suppressor of Cytokine Signaling 7 (SOCS-7), a vital component of the SOCS protein family involved in the regulation of intracellular signaling cascades. SOCS-7 plays a pivotal role in fine-tuning cellular responses to cytokines, insulin, and growth hormones, acting as a feedback controller to prevent excessive or prolonged signaling. Chemical compounds falling within the category of SOCS-7 activators are characterized by their potential to influence this regulatory protein, either directly or indirectly, leading to enhanced SOCS-7 expression or activity.
Within this class, one can find a diverse array of chemical agents, each with distinct mechanisms of action. Some SOCS-7 activators operate by triggering the transcription and translation of SOCS-7, thus promoting its expression levels. Others may modulate signaling pathways that intersect with SOCS-7's functions, ultimately leading to the activation of SOCS-7 as a negative feedback mechanism. While the specific modes of action may vary among these activators, the common goal is to bolster SOCS-7's role in regulating cellular responses, thereby contributing to the maintenance of balanced immune responses, insulin sensitivity, and growth hormone signaling. These activators hold great promise in research and experimental settings, where a deeper understanding of SOCS-7 and its associated pathways is crucial for unraveling the intricacies of cellular signaling and its potential implications for various physiological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
JAK inhibitor that directly triggers modulation of the JAK-STAT signaling pathway, potentially activating SOCS-7 by inhibiting key components of the cytokine response cascade. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3K inhibitor that indirectly triggers SOCS-7 by impeding the insulin signaling pathway, a pathway tightly linked to SOCS-7 activation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor that indirectly activates SOCS-7 through its impact on the mTOR pathway, which plays a role in insulin-related signaling. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Insulin sensitizer that directly enhances insulin sensitivity, potentially activating SOCS-7-mediated regulation of insulin signaling. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Thiazolidinedione and insulin sensitizer that may directly or indirectly activate SOCS-7 by improving insulin sensitivity, a process closely related to SOCS-7 function. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Modulator of mRNA stability, which could indirectly activate SOCS-7 expression by impacting the stability of its mRNA transcripts. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $130.00 $196.00 $274.00 $512.00 $731.00 $1408.00 $2091.00 | 114 | |
STAT inhibitor that directly triggers the inhibition of STAT proteins in signaling pathways, potentially activating SOCS-7 expression and function. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
Vitamin E with peroxidation-inhibiting properties that indirectly activates SOCS-7 by reducing oxidative stress, a factor that can affect signaling pathways in which SOCS-7 participates. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AMPK activator that directly activates AMPK, an enzyme linked to SOCS-7-related energy regulation pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
PDE inhibitor that indirectly activates SOCS-7 by impacting cyclic AMP levels, which are involved in several signaling pathways activated by SOCS proteins. | ||||||