Smac Activators
The chemical class of Smac activators, as identified above, includes compounds that indirectly enhance Smac's role in apoptosis. These activators work primarily by augmenting apoptosis through various pathways, thereby increasing the requirement for Smac's IAP antagonizing function. Compounds like Staurosporine and Sanguinarine induce apoptosis through kinase inhibition and ROS generation, respectively. Such induction can elevate the need for Smac to counteract the effects of IAPs, enhancing its role in the apoptotic process. Similarly, BH3 mimetics like ABT-737, which antagonize Bcl-2 family proteins, directly promote apoptosis, increasing Smac's functional significance in these pathways.
Other activators, including Tunicamycin and Thapsigargin, induce ER stress, leading to apoptosis. These stressors can heighten the demand for Smac in the apoptotic signaling cascade. Physical agents like UVC radiation, which cause DNA damage and apoptosis, also play a role in enhancing Smac's activity. Agents such as Cisplatin and 5-Fluorouracil, which induce apoptosis through DNA damage and antimetabolite action, respectively, contribute to this class by increasing the cellular reliance on Smac for efficient apoptosis. In summary, Smac activators consist of a range of compounds and physical agents that indirectly increase Smac's activity by enhancing apoptotic signaling in cells. These activators do not directly target Smac but increase the cellular need for Smac's function in counteracting IAPs and promoting apoptosis, thereby enhancing its role in the apoptotic process.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor known to induce apoptosis in a variety of cell types. By promoting apoptotic signaling, Staurosporine can increase the cellular demand for Smac, enhancing its role in counteracting IAPs. | ||||||
Sanguinarium | 2447-54-3 | sc-473396 | 10 mg | $220.00 | ||
An alkaloid that induces apoptosis through the generation of reactive oxygen species (ROS). This induction can enhance Smac's role in apoptosis, as increased ROS can lead to mitochondrial dysfunction and Smac release. | ||||||
ABT 737 | 852808-04-9 | sc-207242 | 2.5 mg | $204.00 | 54 | |
ABT-737 mimics BH3-only proteins, antagonizing Bcl-2 family proteins and promoting apoptosis. This action can enhance the role of Smac in apoptotic pathways by increasing the need for its IAP antagonizing function. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
An inducer of ER stress leading to apoptosis through the unfolded protein response. Tunicamycin’s action can result in enhanced apoptotic signaling, thereby potentially upregulating Smac's activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
A SERCA pump inhibitor that induces ER stress and calcium dysregulation, leading to apoptosis. This induction can increase Smac's functional significance in the apoptotic process. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Induces oxidative stress, leading to apoptosis. By enhancing stress-induced apoptotic pathways, Sodium Arsenite can indirectly promote Smac's role in apoptosis. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
A pentacyclic triterpenoid that induces mitochondria-dependent apoptosis. This induction can augment Smac's involvement in counteracting IAPs during apoptosis. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
A topoisomerase I inhibitor that induces DNA damage and apoptosis. This induction can increase the cellular reliance on Smac for effective apoptosis. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
A chemotherapy drug that induces apoptosis through DNA damage. Cisplatin's apoptotic induction can augment the functional requirement of Smac in the cell death process. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
An antimetabolite that induces apoptosis via thymidylate synthase inhibition, leading to DNA damage. This induction can increase Smac's involvement in apoptotic signaling. | ||||||