SLITRK1 Inhibitors
SLITRK1 inhibitors constitute a unique chemical class of compounds designed to interact with and modulate the activity of the SLIT and NTRK-like family member 1 (SLITRK1) protein. SLITRK1 is a neuronally expressed transmembrane protein that plays a crucial role in neuronal development and synaptic function, making it an intriguing target for scientific investigation. Inhibitors tailored for SLITRK1 aim to regulate its activity within neurons and uncover its intricate involvement in various neurobiological processes.
These inhibitors are meticulously crafted to specifically interact with SLITRK1, aiming to alter its functions without affecting other proteins or cellular processes. This selectivity is paramount in the research community, as it enables scientists to dissect the precise roles of SLITRK1 in neurodevelopment and synaptic plasticity. By using SLITRK1 inhibitors, researchers can gain a deeper understanding of the molecular and cellular mechanisms governed by this protein, unraveling the complex networks of signaling pathways and interactions that underlie neuronal development and synaptic transmission. The study of SLITRK1 inhibitors not only offers insights into the fundamental biology of the nervous system but also paves the way for potential discoveries that could have broader implications for neuroscience and our understanding of neurodevelopmental processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GSK 2606414 | 1337531-36-8 | sc-490182 sc-490182A | 5 mg 25 mg | $163.00 $572.00 | ||
GSK2606414 is a selective inhibitor of PERK (EIF2AK3), a kinase that plays a role in the unfolded protein response (UPR). By targeting PERK, it reduces phosphorylation of eIF2α, which ultimately affects protein translation and UPR signaling. | ||||||
STF 083010 | 307543-71-1 | sc-474562 sc-474562A sc-474562B sc-474562C sc-474562D | 5 mg 10 mg 50 mg 100 mg 200 mg | $130.00 $184.00 $408.00 $714.00 $1236.00 | 3 | |
STF-083010 is an AMPK activator that induces cellular energy stress by inhibiting glucose uptake. This indirectly affects SLITRK1 by modulating downstream signaling pathways involved in metabolic regulation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542 is a potent inhibitor of TGF-β receptor type I (ALK5) kinase. TGF-β signaling can interact with SLITRK1 pathways in certain cellular contexts. | ||||||
AG-490 | 133550-30-8 | sc-202046C sc-202046A sc-202046B sc-202046 | 5 mg 50 mg 25 mg 10 mg | $84.00 $329.00 $223.00 $87.00 | 35 | |
AG-490 is a JAK2 inhibitor that can disrupt JAK-STAT signaling pathways, which may affect downstream SLITRK1 regulation in immune and neuronal cells. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K (phosphoinositide 3-kinase) inhibitor, which can influence intracellular signaling cascades that intersect with SLITRK1 pathways. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB-216763 is a GSK-3 inhibitor that regulates glycogen metabolism and may indirectly affect SLITRK1 through cellular metabolic pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective MEK inhibitor, affecting the MAPK/ERK pathway, which can intersect with SLITRK1 signaling in various cellular contexts. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, which may indirectly impact SLITRK1 by interfering with intracellular signaling pathways involving PI3K. | ||||||