SLC6A15 Activators
SLC6A15 activators encompass a set of chemical compounds that directly or indirectly enhance the functional activity of the SLC6A15 protein, a neutral amino acid transporter. Substrates such as sarcosine, glycine, proline, alanine, leucine, and methionine contribute to the transporter's activity by being actively shuttled across the cell membrane, which in turn enhances the protein's transport capacity. The presence of these substrates ensures that SLC6A15 is engaged in continuous transport activity, thereby increasing its functional turnover rate. Betaine, an osmolyte, also plays a critical role by stabilizing cellular osmotic balance, indirectly supporting SLC6A15's optimal functionality by maintaining cell integrity and the appropriate environment necessary for the transporter's activity. Similarly, taurine and hypotaurine, being conditional substrates, upregulate SLC6A15 activity by providing additional substrates for transport, thus directly increasing the protein's workload and functional activity.
Furthermore, the activity of SLC6A15 is influenced by the availability of specific amino acids such as pipecolic acid and L-threonine, which, by serving as substrates, directly enhance the transporter's activity. The transporter's function is directly proportional to the transport rates of these amino acids, making them integral to the protein's activation. N-methyl-D-aspartic acid (NMDA), while not a direct substrate, is included due to its potential to modulate the synaptic environment, which could have downstream effects on neurotransmitter transporter activity, including SLC6A15. By affecting the broader synaptic signaling milieu, NMDA may indirectly facilitate an increase in SLC6A15 activity, complementing the direct substrate-based activation provided by the aforementioned amino acids. Collectively, these SLC6A15 activators enhance the protein's functional activity through substrate-driven transport facilitation and modulation of the cellular environment conducive to the protein's optimal performance.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Betaine serves as an osmolyte and methyl donor and can enhance the activity of SLC6A15 by promoting cellular osmoregulation and methylation processes, which may affect the protein's expression levels and transport function. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $48.00 $102.00 | 1 | |
Taurine, another osmolyte, can indirectly enhance SLC6A15 activity by stabilizing cell volume and possibly affecting the transporter's conformational state, thus modulating its function in amino acid transport. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
Glycine may act as a substrate for SLC6A15 and when present in high concentrations, it can enhance the functional activity of SLC6A15 by increasing the substrate availability for transport, which is the primary function of SLC6A15. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $60.00 $90.00 $325.00 $1155.00 $3851.00 $10056.00 | 2 | |
Vitamin B12 is involved in the one-carbon metabolism pathway, which is critical for methylation processes that can influence the activity of transport proteins like SLC6A15 by modifying the intracellular environment or transporter itself. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAMe serves as a primary methyl donor in methylation reactions and could enhance SLC6A15 function by affecting the methylation status of the protein or associated regulatory elements, potentially altering transporter activity. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folate plays a critical role in one-carbon metabolism and methylation processes, which can indirectly enhance SLC6A15 activity through epigenetic modifications or by affecting the transporter's substrate affinity or turnover rate. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
Magnesium acts as a cofactor in numerous enzymatic reactions, including those that may affect transporter function, and thus may enhance SLC6A15 activity by modulating the activity of enzymes that modify the transporter's function or localization. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is important for the proper function of many proteins, and could indirectly enhance SLC6A15 function by stabilizing protein structure, affecting transporter assembly, or modulating the activity of enzymes that phosphorylate the transporter and affect its activity. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $62.00 | ||
L-Leucine may act as a substrate for SLC6A15, and by increasing the substrate availability, it could enhance the transporter's activity. Furthermore, as an amino acid, it may regulate the function of SLC6A15 through cellular signaling pathways that respond to amino acid availability. | ||||||
L-Isoleucine | 73-32-5 | sc-396706 sc-396706A | 25 g 100 g | $28.00 $120.00 | ||
Similar to L-Leucine, L-Isoleucine could enhance SLC6A15 function by increasing substrate availability and influencing cellular metabolic status, which could indirectly affect the activity of the transporter. | ||||||