SLC41A3 Activators
SLC41A3, a transporter pivotal to magnesium homeostasis, plays a key role in magnesium transport. While specific direct activators remain unidentified, understanding the broader context of cellular ionic balances and related transport mechanisms offers insights into potential indirect activators. Compounds like Ouabain and Verapamil, which respectively target the Na+/K+ ATPase and calcium channels, can reshape cellular ionic dynamics, influencing magnesium transporters, including SLC41A3. The antibiotic Erythromycin, although primarily known for its antimicrobial activity, has been noted to impact cellular ion balance, suggesting potential intersections with SLC41A3.
Another significant category encompasses diuretics like Bumetanide, Furosemide, and Spironolactone. By affecting sodium, potassium, and chloride transport, these diuretics can recalibrate cellular ionic levels, casting an indirect influence on magnesium transport mechanisms and potentially modulating SLC41A3 function. Ethacrynic Acid and Hydrochlorothiazide, both known for their diuretic properties, specifically influence sodium reabsorption, offering another route to potentially modulate the activity of magnesium transporters such as SLC41A3. Collectively, these compounds, by affecting various aspects of cellular ionic regulation, underscore the intricate network where SLC41A3 function and expression can be modulated.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ouabain-d3 (Major) | sc-478417 | 1 mg | $516.00 | |||
Cardiac glycoside that inhibits Na+/K+ ATPase, potentially influencing cellular magnesium balance and indirectly affecting SLC41A3 activity. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Calcium channel blocker which can influence cellular ionic balances, indirectly affecting magnesium transporters like SLC41A3. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Antibiotic that alters cellular ion balance. This can have an indirect influence on magnesium transporters including SLC41A3. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Calcium channel blocker that affects cellular calcium levels, potentially influencing magnesium transporters such as SLC41A3 indirectly. | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $109.00 $228.00 | 9 | |
Loop diuretic which inhibits the Na+-K+-2Cl- symporter and affects cellular ion balance, potentially influencing SLC41A3. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $41.00 | ||
Loop diuretic affecting sodium and potassium transport, which can indirectly impact magnesium transporters like SLC41A3. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $109.00 | 3 | |
Aldosterone antagonist which affects sodium and potassium balance, indirectly influencing magnesium transporters like SLC41A3. | ||||||
Chlorothiazide | 58-94-6 | sc-202536 sc-202536A sc-202536B | 1 g 5 g 10 g | $39.00 $107.00 $175.00 | ||
Thiazide diuretic influencing sodium and chloride reabsorption, potentially affecting magnesium transport via SLC41A3. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $90.00 $300.00 | 5 | |
Loop diuretic affecting sodium and chloride transport, potentially influencing magnesium transporters like SLC41A3. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $55.00 $240.00 $333.00 $562.00 $988.00 | ||
Thiazide diuretic affecting sodium reabsorption, potentially impacting magnesium transporters such as SLC41A3. | ||||||