SLC41A3 Inhibitors
The SLC41A3 inhibitors constitute a diverse cohort of chemicals, each characterized by unique mechanisms of action, collectively exerting regulatory influence on SLC41A3 within cellular contexts. SLC41A3, a member of the solute carrier family, functions as a sodium-magnesium exchanger pivotal to ion homeostasis. Its regulatory role in maintaining cellular ionic equilibrium makes it an attractive target for modulation through chemical interventions. Ammonium Chloride and Ouabain, acting as disruptors of ion balance, particularly sodium, profoundly impact the electrochemical gradient across cellular membranes. This perturbation intricately modulates SLC41A3, altering its function and subsequently influencing the cellular ion milieu. SKF-96365 and 2-Aminoethoxydiphenyl borate (2-APB) intervene in calcium signaling pathways, indirectly affecting SLC41A3 by modifying intracellular calcium levels. Amiloride and Gadolinium, targeting ENaC (Epithelial Sodium Channel) and calcium channels, respectively, induce changes in sodium concentrations and calcium dynamics, thereby indirectly influencing the regulatory landscape of SLC41A3. N-Ethylmaleimide and Ruthenium Red, with their modulatory effects on redox status, exert influence over redox-sensitive pathways involved in the intricate regulation of SLC41A3.
Ethoxyquin, Gadolinium chloride, and Vanadate extend the scope of understanding by highlighting the impact of redox modulation and disruption of ion balance on SLC41A3. YM-244769, a specific inhibitor of Store-Operated Calcium Entry (SOCE), offers a targeted approach to modulating calcium dynamics, thereby indirectly affecting the regulatory pathways of SLC41A3. Collectively, this array of inhibitors serves as a sophisticated toolkit for researchers, facilitating in-depth exploration of the intricate cellular pathways orchestrating the regulation of SLC41A3 and its crucial role in maintaining ion homeostasis. The comprehensive elucidation of these chemical interactions contributes significantly to the advancement of our understanding of SLC41A3 regulation in diverse cellular contexts. The intricate interplay between these inhibitors and the multifaceted machinery governing SLC41A3 highlights the complexity of cellular ion homeostasis and underscores the importance of precise regulation in maintaining cellular functionality.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ammonium Chloride | 12125-02-9 | sc-202936 sc-202936A sc-202936B | 25 g 500 g 2.5 kg | $38.00 $54.00 $147.00 | 4 | |
Ammonium Chloride disrupts cellular ion balance, impacting the homeostasis of sodium and potassium. This influences the intracellular environment, indirectly modulating SLC41A3, a sodium-magnesium exchanger. The altered ion balance can lead to changes in the electrochemical gradient, affecting the transport activity of SLC41A3 and subsequently modulating its regulation within the cell. | ||||||
Ouabain Octahydrate | 11018-89-6 | sc-201548 sc-201548A | 1 g 5 g | $190.00 $720.00 | 11 | |
Ouabain, a cardiac glycoside, inhibits the Na+/K+-ATPase pump. By disrupting ion transport dynamics, especially sodium levels, it indirectly influences SLC41A3. The perturbation in sodium gradients affects the cellular context, potentially altering the regulatory mechanisms of SLC41A3 and its involvement in ion homeostasis. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365 is a non-specific inhibitor of receptor-mediated calcium entry. By modulating calcium influx, it indirectly impacts SLC41A3, a sodium-magnesium exchanger. Changes in intracellular calcium levels can influence the cellular environment, leading to alterations in the regulatory pathways of SLC41A3 and its role in maintaining ion balance, highlighting its indirect modulation by calcium-dependent signaling cascades. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-Aminoethoxydiphenyl borate (2-APB) inhibits IP3 receptor-mediated calcium release. By interfering with calcium signaling, it indirectly influences SLC41A3, a sodium-magnesium exchanger. Altered calcium dynamics affect the cellular context, potentially impacting the regulatory mechanisms of SLC41A3 and its involvement in ion homeostasis through modulation of IP3 receptor-dependent calcium release pathways. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride is a selective inhibitor of the epithelial sodium channel (ENaC). By targeting ENaC, it indirectly influences sodium concentrations, impacting the cellular environment. This modulation of sodium levels can lead to indirect effects on SLC41A3, a sodium-magnesium exchanger, altering its regulatory pathways and involvement in maintaining ion balance within the cell. | ||||||
Gadolinium | 7440-54-2 | sc-250038 | 10 g | $87.00 | ||
Gadolinium is a non-specific inhibitor of various calcium channels. By interfering with calcium entry, it indirectly influences SLC41A3, a sodium-magnesium exchanger. Changes in intracellular calcium levels affect the cellular environment, potentially altering the regulatory mechanisms of SLC41A3 and its role in maintaining ion balance through modulation of calcium channel-dependent signaling cascades. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $68.00 $210.00 $780.00 $1880.00 | 19 | |
N-Ethylmaleimide (NEM) inhibits thiol-containing enzymes, impacting cellular redox status. This redox modulation indirectly influences SLC41A3, a sodium-magnesium exchanger, as redox-sensitive pathways are involved in its regulation. Changes in the cellular redox environment can alter the regulatory mechanisms of SLC41A3, highlighting its indirect modulation through redox-dependent signaling cascades. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red inhibits various calcium channels. By interfering with calcium entry, it indirectly influences SLC41A3, a sodium-magnesium exchanger. Changes in intracellular calcium levels affect the cellular environment, potentially altering the regulatory mechanisms of SLC41A3 and its role in maintaining ion balance through modulation of calcium channel-dependent signaling cascades. | ||||||
Ethoxyquin | 91-53-2 | sc-205686 sc-205686A | 100 g 250 g | $61.00 $122.00 | ||
Ethoxyquin is an antioxidant that influences cellular redox status. By modulating redox pathways, it indirectly impacts SLC41A3, a sodium-magnesium exchanger, as redox-sensitive mechanisms are involved in its regulation. Changes in the cellular redox environment can alter the regulatory mechanisms of SLC41A3, highlighting its indirect modulation through redox-dependent signaling cascades. | ||||||
Gadolinium(III) chloride | 10138-52-0 | sc-224004 sc-224004A | 5 g 25 g | $150.00 $350.00 | 4 | |
Gadolinium chloride is a non-specific inhibitor of various calcium channels. By interfering with calcium entry, it indirectly influences SLC41A3, a sodium-magnesium exchanger. Changes in intracellular calcium levels affect the cellular environment, potentially altering the regulatory mechanisms of SLC41A3 and its role in maintaining ion balance through modulation of calcium channel-dependent signaling cascades. | ||||||