SLC39A13 Activators
SLC39A13 Activators are a collection of chemical compounds that indirectly influence the functional activity of SLC39A13, primarily involved in the cellular transport of zinc. Compounds such as Zinc Pyrithione and Zinc sulfate directly increase the availability of zinc ions, the substrate for the SLC39A13 transporter, which may lead to its enhanced activity to maintain zinc homeostasiswithin the cell. By providing an abundance of substrate, these compounds effectively stimulate the transporter to regulate the intracellular zinc levels. Similarly, chelating agents like Histidine, D-penicillamine, EDTA, TPEN, and N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine function to sequester zinc ions, which could trigger a compensatory response by SLC39A13 to reestablish the crucial intracellular zinc balance. The increased need for zinc homeostasis precipitated by these chelators would conceivably lead to an increase in the activity of SLC39A13 to facilitate zinc uptake and distribution within the cell.
Chloroquine and Clioquinol, through their actions on lysosomal function and metal ion binding, respectively, may create a cellular environment that necessitates the upregulation of zinc transport processes, indirectly leading to the augmented activity of SLC39A13. Nitric oxide donors like SNAP, which modulate various cellular pathways including metal ion homeostasis, could also indirectly promote the activity of SLC39A13 in response to changes in zinc metabolism. Deferasirox, while primarily an iron chelator, may influence zinc homeostasis as well, potentially leading to an increase in SLC39A13 activity as part of a broader effort to regulate metal ion concentrations within the cell. Collectively, these activators work through diverse biochemical mechanisms, yet they converge on the common goal of enhancing the functional activity of SLC39A13 in the management of zinc transport and homeostasis within the cellular milieu.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
1-Hydroxypyridine-2-thione zinc salt is a coordination complex of zinc. SLC39A13 is a zinc transporter; thus, Zinc Pyrithione can enhance the functional activity of SLC39A13 by increasing the availability of zinc ions, which are essential for the transporter's activity in cellular zinc homeostasis. | ||||||
L-Histidine | 71-00-1 | sc-394101 sc-394101A sc-394101B sc-394101C sc-394101D | 25 g 100 g 250 g 500 g 1 kg | $54.00 $84.00 $189.00 $204.00 $339.00 | 1 | |
Histidine is an amino acid that can chelate zinc ions. By chelating zinc, Histidine increases the intracellular demand for zinc, which could indirectly lead to the enhanced activity of SLC39A13 as the protein works to replenish zinc levels within cells. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is known to interfere with lysosomal function and autophagy. Through this interference, it can cause an accumulation of zinc in lysosomes, potentially requiring the action of zinc transporters like SLC39A13 to re-establish zinc homeostasis. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $33.00 $64.00 | 11 | |
PDTC is a metal chelator and antioxidant. By chelating heavy metals, it can influence the intracellular distribution of zinc and possibly enhance the activity of SLC39A13 as the protein compensates for altered zinc availability. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
D-penicillamine is a chelating agent used to bind metals. It can bind to zinc ions, creating a higher demand for zinc uptake and potentially increasing the activity of zinc transporters like SLC39A13 to maintain zinc homeostasis. | ||||||
TPEN | 16858-02-9 | sc-200131 | 100 mg | $130.00 | 10 | |
TPEN (N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine) is a high-affinity zinc chelator. It can deplete intracellular zinc levels, which may lead to compensatory upregulation of SLC39A13 activity to restore zinc homeostasis. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $74.00 $114.00 $374.00 | 18 | |
Nitric oxide donors like S-Nitroso-N-acetyl-DL-penicillamine (SNAP) can modulate a variety of cellular pathways, including metal ion homeostasis. By influencing these pathways, SNAP may indirectly enhance the activity of SLC39A13 in regulating zinc transport and distribution. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $45.00 $115.00 | 2 | |
Clioquinol is a metal chelator and antibiotic that can bind to zinc ions. This binding could create a cellular state that compensates for the reduction in available zinc by upregulating zinc transporter proteins like SLC39A13. | ||||||
Deferasirox | 201530-41-8 | sc-207509 | 2.5 mg | $180.00 | 9 | |
Deferasirox is an iron chelator that may also affect the homeostasis of other metal ions, including zinc. It could indirectly increase the activity of SLC39A13 as the protein adjusts to maintain zinc balance when iron and potentially zinc levels are affected by the chelation. | ||||||