SLC38A7 Activators
SLC38A7 Activators are a diverse group of chemical compounds that can directly or indirectly enhance the functional activity of SLC38A7, a solute carrier protein. For instance, Resveratrol and Forskolin enhance SLC38A7 activity indirectly by activating the SIRT1 and adenylate cyclase pathways respectively. The SIRT1 pathway, when activated by Resveratrol, leads to the deacetylation of numerous proteins which can increase SLC38A7 functional activity. Similarly, Forskolin's activation of the adenylate cyclase pathway increases the intracellular levels of cAMP, a second messenger. Increased cAMP levels enhance SLC38A7 functional activity by upregulating its transport efficiency.
Furthermore, Capsaicin and Piperine activate the TRPV1 pathway, leading to changes in ionic balance in the cell. These changes can indirectly enhance SLC38A7 functional activity by optimizing its transport conditions. Other compounds like EGCG, Curcumin, Silymarin, Quercetin, and Genistein inhibit pathways that produce proteins known to negatively regulate SLC38A7, thereby indirectly enhancing its activity. For instance, EGCG and Silymarin inhibit the NF-κB pathway, reducing the transcription of such negative regulators. Similarly, Curcumin and Genistein inhibit the JAK-STAT and PI3K/AKT pathways respectively, reducing the production of proteins that negatively regulate SLC38A7. Thus, these SLC38A7 Activators use a variety of biochemical and cellular pathways to enhance the functional activity of SLC38A7.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol, activates the SIRT1 pathway. SIRT1, a NAD+-dependent deacetylase, deacetylates numerous proteins. This activity can enhance the function of SLC38A7, as SIRT1-mediated deacetylation events can increase SLC38A7 functional activity indirectly. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, a labdane diterpene, activates the adenylate cyclase pathway. This activation increases intracellular levels of cAMP, a second messenger. Increased cAMP levels can enhance SLC38A7 functional activity by upregulating its transport efficiency. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin that inhibits the NF-κB pathway. NF-κB is a family of transcription factors that can indirectly enhance the functional activity of SLC38A7 by reducing the transcription of proteins that negatively regulate SLC38A7. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a polyphenolic compound that inhibits the JAK-STAT pathway. By inhibiting this pathway, Curcumin can reduce the production of proteins that negatively regulate SLC38A7, thus enhancing its functional activity. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates the TRPV1 pathway, which can lead to changes in ionic balance in the cell. These changes can indirectly enhance SLC38A7 functional activity by optimizing its transport conditions. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin activates the AMPK pathway. AMPK is a cellular energy sensor that regulates metabolism and energy homeostasis. The activation of AMPK can enhance the functional activity of SLC38A7 by optimizing the cellular energy status for its operation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, inhibits the PI3K/AKT pathway. By inhibiting this pathway, Quercetin can reduce the production of proteins that negatively regulate SLC38A7, enhancing its functional activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates the AMPK pathway, similar to Metformin. Activation of AMPK can enhance the functional activity of SLC38A7 by optimizing the cellular energy status for its operation. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $325.00 | ||
Silymarin is a flavonoid that inhibits the NF-κB pathway, similar to EGCG. Inhibition of NF-κB can indirectly enhance the functional activity of SLC38A7 by reducing the transcription of proteins that negatively regulate SLC38A7. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone, inhibits the PI3K/AKT pathway, similar to Quercetin. By inhibiting this pathway, Genistein can reduce the production of proteins that negatively regulate SLC38A7, enhancing its functional activity. | ||||||