SLC38A11 Inhibitors
SLC38A11 Inhibitors are selected based on their ability to influence amino acid transport, particularly focusing on sodium-dependent and proton antiport activities. As a putative sodium-coupled neutral amino acid transporter, SLC38A11's activity might be influenced by changes in sodium and proton gradients, which are essential for the antiport mechanism. Inhibitors of epithelial sodium channels, such as Amiloride, and Na⁺/K⁺-ATPase inhibitors like Ouabain-d3 (Major), could affect the sodium gradient, impacting the transport activity of SLC38A11. Amino acid analogs, including lysine, tryptophan, and glutamine analogs, might serve as competitive inhibitors or alternative substrates, providing insights into the substrate specificity and transport mechanism of SLC38A11.
Compounds like 2-Amino-2-norbornanecarboxylic acid and N-Methyl-alpha-aminoisobutyric acid hydrochloride, known to inhibit specific amino acid transport systems, along with Acivicin, could be used to study the transport characteristics and functional role of SLC38A11. Additionally, agents like Hydrochlorothiazide and 12β-Hydroxydigitoxin that modulate ion transport, and Metformin, which affects cellular metabolism, may indirectly influence amino acid transport processes involving SLC38A11. These compounds offer valuable tools for research into the roles of amino acid transporters in cellular physiology and pathology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride is a diuretic that inhibits epithelial sodium channels, potentially impacting sodium-dependent transport processes relevant to SLC38A11. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain-d3 (Major) inhibits the Na⁺/K⁺-ATPase pump, potentially affecting sodium gradients crucial for sodium-dependent amino acid transporters like SLC38A11. | ||||||
THIP hydrochloride | 64603-91-4 | sc-204342 | 50 mg | $152.00 | 2 | |
THIP hydrochloride, a selective GABA agonist, might influence GABAergic signaling and indirectly affect amino acid transport systems, including those like SLC38A11. | ||||||
Cadaverine | 462-94-2 | sc-239454 | 10 ml | $212.00 | ||
Lysine analogs like Cadaverine can competitively inhibit amino acid transporters, potentially affecting the function of SLC38A11 in amino acid transport. | ||||||
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $102.00 $408.00 $642.00 $1275.00 | 10 | |
Acivicin is a reported inhibitor of amino acid transporters and could indirectly influence the function of SLC38A11. | ||||||
2-Amino-2-norbornanecarboxylic acid | 20448-79-7 | sc-237901 | 100 mg | $178.00 | 1 | |
2-Amino-2-norbornanecarboxylic acid is an inhibitor of system L amino acid transporters and could provide insights into the function of similar transporters like SLC38A11. | ||||||
N-Methyl-alpha-aminoisobutyric acid hydrochloride | 2566-34-9 | sc-286416 sc-286416A | 250 mg 1 g | $83.00 $180.00 | ||
N-Methyl-alpha-aminoisobutyric acid hydrochloride is a substrate analog for system A amino acid transporters, potentially affecting competitive transport processes involving SLC38A11. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $54.00 $235.00 $326.00 $551.00 $969.00 | ||
Hydrochlorothiazide affects sodium transport and could indirectly impact sodium-dependent amino acid transporters like SLC38A11. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $140.00 $680.00 | ||
12β-Hydroxydigitoxin affects sodium-calcium exchange and could indirectly influence sodium-dependent transport mechanisms relevant to SLC38A11. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin influences cellular metabolism and could indirectly affect amino acid transport processes involving SLC38A11. | ||||||