Molecular structure of 2-Amino-2-norbornanecarboxylic acid, CAS Number: 20448-79-7
2-Amino-2-norbornanecarboxylic acid (CAS 20448-79-7)
See product citations (1)
Alternate Names:
2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid; BCH
Application:
2-Amino-2-norbornanecarboxylic acid is An inhibitor of amino acid transport across cell membranes
CAS Number:
20448-79-7
Purity:
≥97%
Molecular Weight:
155.19
Molecular Formula:
C8H13NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
2-Amino-2-norbornanecarboxylic acid, also known as 2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid (2-ABCA), plays a role as an intermediate in the synthesis of various biologically active compounds. This chemical′s unique structure is used to probe the conformational stability of peptides and proteins. Its utilized to synthesize peptidomimetics, which are compounds that mimic the structure of peptides and can provide insight into protein folding and stability. It is known to engage with specific receptors that are implicated in metabolic regulation. Such as PPARγ, which plays a role in managing fatty acid metabolism, suggesting 2-Amino-2-norbornanecarboxylic acid′s involvement in modulating receptor functions.
2-Amino-2-norbornanecarboxylic acid (CAS 20448-79-7) References
- Metabolic and ionic coupling factors in amino acid-stimulated insulin release in pancreatic beta-HC9 cells. | Doliba, NM., et al. 2007. Am J Physiol Endocrinol Metab. 292: E1507-19. PMID: 17264232
- Neutral amino acid transport by isolated small intestinal cells from guinea pigs. | Del Castillo, JR. and Muñiz, R. 1991. Am J Physiol. 261: G1030-6. PMID: 1767844
- Enhancing effect of zinc on L-histidine transport in rat lung microvascular endothelial cells. | Sakurai, E., et al. 2011. Biol Trace Elem Res. 142: 713-22. PMID: 20721638
- Putative transport mechanism and intracellular fate of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in human prostate cancer. | Okudaira, H., et al. 2011. J Nucl Med. 52: 822-9. PMID: 21536930
- Synthesis and biological evaluation of ¹⁸F-labeled fluoropropyl tryptophan analogs as potential PET probes for tumor imaging. | Chiotellis, A., et al. 2013. Eur J Med Chem. 70: 768-80. PMID: 24239624
- Oral and intravenous pharmacokinetics of taurine in sprague-dawley rats: the influence of dose and the possible involvement of the proton-coupled amino acid transporter, PAT1, in oral taurine absorption. | Nielsen, CU., et al. 2017. Physiol Rep. 5: PMID: 29038364
- Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex. | Yan, R., et al. 2019. Nature. 568: 127-130. PMID: 30867591
- Regulation of Melanogenesis by the Amino Acid Transporter SLC7A5. | Gaudel, C., et al. 2020. J Invest Dermatol. 140: 2253-2259.e4. PMID: 32240722
- Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis. | Markowicz-Piasecka, M., et al. 2020. Apoptosis. 25: 426-440. PMID: 32405891
- Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2. | Fitzgerald, E., et al. 2021. Sci Rep. 11: 9092. PMID: 33907288
- Thyroid Hormone Transporters in a Human Placental Cell Model. | Chen, Z., et al. 2022. Thyroid. 32: 1129-1137. PMID: 35699060
- Methylmercury-thiol uptake into cultured brain capillary endothelial cells on amino acid system L. | Mokrzan, EM., et al. 1995. J Pharmacol Exp Ther. 272: 1277-84. PMID: 7891344
- Glutamine uptake at the blood-brain barrier is mediated by N-system transport. | Ennis, SR., et al. 1998. J Neurochem. 71: 2565-73. PMID: 9832157
Inhibitor of:
GlcNAc kinase, GPx-8, LAT1, SLC38A11, and SNAT1.Activator of:
SLC7A6, and Y+LAT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Amino-2-norbornanecarboxylic acid, 100 mg | sc-237901 | 100 mg | $182.00 |