SK3 Inhibitors
The chemical class of SK3 inhibitors encompasses a diverse repertoire of compounds meticulously chosen for their specific interactions with SK3 channels, integral players in the regulation of cellular excitability through potassium ion modulation. Apamin, a peptide toxin found in bee venom, represents a direct inhibitor within this class. By selectively binding to SK3 channels and occluding the pore, apamin impedes the flow of potassium ions, resulting in the inhibition of SK3 channel activity. This blockade induces alterations in membrane potential and cellular excitability, elucidating apamin's role as a targeted tool for investigating the physiological functions of SK3 channels.
Moreover, synthetic peptide inhibitors such as Lei-Dab7 and tamapin contribute to this chemical class by specifically targeting SK3 channels. Lei-Dab7, designed to selectively bind and block the channels, obstructs the passage of potassium ions, leading to the inhibition of SK3 activity. The class also includes small molecules like NS8593, which exhibit nuanced actions on SK3 channels, acting as both positive modulators and inhibitors, depending on concentration. These chemicals, along with others listed, collectively form a comprehensive toolkit for researchers to explore the complex dynamics of SK3 channels, shedding light on the intricacies of potassium ion flux and its impact on cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Apamin | 24345-16-2 | sc-200994 sc-200994A | 500 µg 1 mg | $168.00 $280.00 | 7 | |
Apamin, a peptide toxin, is a well-known and direct inhibitor of SK channels, including SK3. By binding to the channels and occluding the pore, apamin prevents the flow of potassium ions, effectively inhibiting SK3 channel activity. This inhibition leads to changes in membrane potential and cellular excitability. | ||||||
UCL 2077 | 918311-87-2 | sc-204371 sc-204371A | 10 mg 50 mg | $135.00 $575.00 | ||
UCL2077, a selective SK channel blocker, exerts its inhibitory effect on SK3 channels by interfering with their activation. This small molecule inhibits the calcium sensitivity of SK3 channels, preventing their opening and reducing potassium ion conductance. | ||||||
TRAM-34 | 289905-88-0 | sc-201005 sc-201005A | 5 mg 25 mg | $193.00 $607.00 | 10 | |
TRAM-34, a potent and selective SK3 channel inhibitor, modulates channel activity by interfering with the binding of calmodulin to the calmodulin-binding domain. This disruption inhibits the calcium-dependent activation of SK3, leading to decreased potassium ion conductance. | ||||||
Iberiotoxin | 129203-60-7 | sc-3585 sc-3585A | 10 µg 100 µg | $270.00 $490.00 | 16 | |
Iberiotoxin, a scorpion venom-derived peptide, is a potent and selective inhibitor of SK channels, including SK3. By binding to the channels and blocking their pore, iberiotoxin prevents the flow of potassium ions, leading to the inhibition of SK3 channel activity. This inhibition induces changes in membrane potential and cellular excitability. | ||||||
Charybdotoxin | 95751-30-7 | sc-200979 | 100 µg | $401.00 | 9 | |
Charybdotoxin, a peptide toxin from scorpion venom, is a broad-spectrum inhibitor of SK channels, including SK3. By binding to the channels and blocking the pore, charybdotoxin inhibits the flow of potassium ions, leading to the inhibition of SK3 channel activity. | ||||||