SK3 Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CyPPA | 73029-73-9 | sc-205281 sc-205281A | 10 mg 50 mg | $145.00 $645.00 | ||
CyPPA is a potent modulator of small-conductance calcium-activated potassium (SK) channels, distinguished by its selective binding to the channel's extracellular regions. This interaction induces conformational changes that enhance channel opening, facilitating ion flow. The compound exhibits unique reaction kinetics, with a rapid association rate that allows for swift modulation of channel activity. Additionally, CyPPA's hydrophobic characteristics promote effective membrane penetration, influencing its bioavailability and interaction with lipid bilayers. | ||||||
NS309 | 18711-16-5 | sc-253202 | 5 mg | $110.00 | ||
NS309, a small molecule activator, directly activates SK3 channels. NS309 binds to the calmodulin-binding domain of SK3, leading to the potentiation of channel opening. This direct activation enhances the flow of potassium ions through SK3 channels, modulating membrane potential and influencing cellular processes dependent on SK3 channel activity. | ||||||
1-EBIO | 10045-45-1 | sc-201695 sc-201695A | 10 mg 50 mg | $87.00 $325.00 | 1 | |
EBIO, a chemical activator, directly stimulates SK channels, including SK3, by enhancing channel opening. EBIO's activation of SK3 is mediated by an increase in intracellular calcium concentration, leading to the potentiation of channel activity. This direct modulation of SK3 by EBIO offers a valuable tool for studying the physiological roles of SK3 channels and their impact on cellular processes such as neuronal excitability. | ||||||
DCEBIO | 60563-36-2 | sc-203561 sc-203561A | 10 mg 50 mg | $107.00 $417.00 | 3 | |
DCEBIO, a positive modulator of SK channels, including SK3, enhances channel opening and promotes potassium ion conductance. By modulating the calcium sensitivity of SK3, DCEBIO directly influences channel activity, impacting cellular processes dependent on SK3 function. | ||||||
Naphthol AS | 92-77-3 | sc-215536A sc-215536 | 25 g 500 g | $42.00 $162.00 | ||
Naphthol AS-E phosphate, a chemical activator, directly stimulates SK channels, including SK3, by promoting calcium sensitivity and channel opening. Through its action on SK3, Naphthol AS-E phosphate increases potassium ion conductance, influencing cellular processes dependent on SK3 channel activity. | ||||||
Ampeloptin | 27200-12-0 | sc-480419 | 10 mg | $300.00 | ||
Ampeloptin, a flavonoid, may act as an indirect activator of SK3 by modulating cellular pathways associated with SK channel regulation. Its potential to influence calcium signaling and cellular redox status suggests a modulatory role in SK3 channel activity. | ||||||