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Apamin: Caution! Highly toxic. Handle with care. The smallest neurotoxin known. It is the only polypeptide neurotoxin that is known to pass the blood-brain barrier. Comprises about 2% by weight of the dried venom of the honey bee. It is a potent (1-10 nM) and highly selective inhibitor of the SK (low conductance Ca2+-activated K+ channel). Acts on the central nervous system. SK channel blockers such as apamin can have therapeutic applications, for example on the peripheral cells (e.g. the insulin releasing cells of the pancreas) and on the central nervous system where there is evidence for a role of SK channels in memory processes, both general and specifically hippocampal.
1: N.A. Castle et al. Trends Neurosci. 1989 12 59 2: M. Hughes et al. Proc. Natl. Acad. Sci. USA 1982 79 1308 3: P.N. Strong Pharmacol. Therap. 1990 46 137
See how others have used Apamin. Click on the entry to view the PubMed entry .
PMID: # 28036359 Estep, CM. et al. 2016. PLoS ONE. 11: e0169044.
PMID: # 25641660 Sung, TS. et al. 2015. J. Physiol. (Lond.). 593: 1169-81.
PMID: # 32086857 FASEB J.
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