Molecular structure of Apamin, CAS Number: 24345-16-2
Apamin (CAS 24345-16-2)
See product citations (7)
Application:
Apamin is a potent and highly selective inhibitor of the low conductance Ca2+-activated K+ channel
CAS Number:
24345-16-2
Purity:
≥95%
Molecular Weight:
2027.34
Molecular Formula:
C79H131N31O24S4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
The smallest neurotoxin known. It is a potent (1-10 nM) and highly selective inhibitor of the SK (low conductance Ca2+-activated K+ channel). Acts on the central nervous system. The specificity of apamin for SK channels makes it an invaluable tool in neuroscience research, helping to elucidate the roles of these channels in various physiological and pathological processes. By blocking SK channels, apamin can increase neuronal excitability and has been used to study the functions of these channels. Apamin′s role in research extends to its use in biochemistry as a selective probe to understand the intricacies of potassium channel operation and their contribution to cellular signaling.
Apamin (CAS 24345-16-2) References
- Apamin-sensitive K+ currents mediate arachidonic acid-induced relaxations of rabbit aorta. | Gauthier, KM., et al. 2004. Hypertension. 43: 413-9. PMID: 14691199
- Apamin reduces neuromuscular transmission by activating inhibitory muscarinic M(2) receptors on motor nerve terminals. | de Matos Silva, LF., et al. 2010. Eur J Pharmacol. 626: 239-43. PMID: 19818752
- Apamin modulates electrophysiological characteristics of the pulmonary vein and the Sinoatrial Node. | Chen, WT., et al. 2013. Eur J Clin Invest. 43: 957-63. PMID: 23834267
- Apamin attenuated cerulein-induced acute pancreatitis by inhibition of JNK pathway in mice. | Bae, GS., et al. 2013. Dig Dis Sci. 58: 2908-17. PMID: 23918150
- The apamin-sensitive Ca2+-dependent K+ channel molecular properties, differentiation and endogenous ligands in mammalian brain. | Lazdunski, M., et al. 1985. Biochem Soc Symp. 50: 31-42. PMID: 2428371
- Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. | Yu, CC., et al. 2014. PLoS One. 9: e96691. PMID: 24798465
- Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: melittin, apamin and mastoparan. | Moreno, M. and Giralt, E. 2015. Toxins (Basel). 7: 1126-50. PMID: 25835385
- Apamin Improves Prefrontal Nicotinic Impairment in Mouse Model of Alzheimer's Disease. | Proulx, É., et al. 2020. Cereb Cortex. 30: 563-574. PMID: 31188425
- Therapeutic Effects of Apamin as a Bee Venom Component for Non-Neoplastic Disease. | Gu, H., et al. 2020. Toxins (Basel). 12: PMID: 32204567
- Apamin as a BBB Shuttle and Its Effects on T Cell Population During the Experimental Autoimmune Encephalomyelitis-Induced Model of Multiple Sclerosis. | Fattahi, H., et al. 2021. Neurotox Res. 39: 1880-1891. PMID: 34487326
- Apamin Enhances Neurite Outgrowth and Regeneration after Laceration Injury in Cortical Neurons. | Kim, H., et al. 2021. Toxins (Basel). 13: PMID: 34564607
- Optimized 2-methoxyestradiol invasomes fortified with apamin: a promising approach for suppression of A549 lung cancer cells. | Awan, ZA., et al. 2022. Drug Deliv. 29: 1536-1548. PMID: 35612292
- Optimized Apamin-Mediated Nano-Lipidic Carrier Potentially Enhances the Cytotoxicity of Ellagic Acid against Human Breast Cancer Cells. | Badr-Eldin, SM., et al. 2022. Int J Mol Sci. 23: PMID: 36012704
Inhibitor of:
Ik1, KCNMB3, KCNN2, KCNT2, LRFN5, MaxiKβ, neurexin III, OR2T34, RCK, SK, SK2, and SK3.Activator of:
KCNRG, KV2.2, and SK1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Apamin, 500 µg | sc-200994 | 500 µg | $168.00 | |||
Apamin, 1 mg | sc-200994A | 1 mg | $280.00 |