SIRT7 Inhibitors

SIRT7 inhibitors belong to a distinct chemical class characterized by their ability to selectively target and inhibit the activity of the Sirtuin 7 (SIRT7) enzyme. SIRT7 is a member of the sirtuin family of NAD+-dependent deacetylases, which play critical roles in cellular processes such as gene expression regulation, DNA repair, and metabolic homeostasis. Specifically, SIRT7 is primarily localized within the cell's nucleus and is known for its involvement in chromatin structure maintenance and gene transcription regulation. Its deacetylase activity is responsible for removing acetyl groups from histone proteins and non-histone substrates, thereby influencing chromatin compaction and modulating the expression of genes associated with various cellular functions.

SIRT7 inhibitors, as the name suggests, are compounds designed to interfere with the enzymatic activity of SIRT7. By binding to the active site of the enzyme or altering its conformation, these inhibitors effectively block SIRT7's deacetylase function. This selective inhibition of SIRT7 can have profound implications for cellular processes and functions that rely on SIRT7's enzymatic activity. Researchers are actively studying these inhibitors to better understand their mechanisms and applications, particularly in the context of basic research and development.