Sin3A complex Inhibitors
The Sin3A complex is a multiprotein corepressor complex that plays a crucial role in the regulation of gene expression and chromatin remodeling. It functions by recruiting histone deacetylases (HDACs) and other chromatin-modifying enzymes to target genes, leading to transcriptional repression. The complex is involved in a wide range of biological processes, including cell cycle regulation, DNA repair, and development. Sin3A complex signaling is characterized by its ability to modify histone proteins through the deacetylation of histone tails, resulting in a condensed and transcriptionally silent chromatin structure. This repression of gene expression is vital for maintaining proper cellular function and aberrant transcription.
The significance of Sin3A complex inhibitors lies in their potential to modulate gene expression and chromatin structure, making them valuable tools in both research and contexts. By targeting HDACs or other components of the Sin3A complex, inhibitors can reverse the repressive effects of the complex, leading to the activation of specific genes. In research, Sin3A complex inhibitors are used to study the functions of the complex, identify its target genes, and explore its role in various biological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
inhibits HDACs, leading to histone hyperacetylation and disrupting Sin3A complex-mediated transcriptional repression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
inhibits HDAC activity, resulting in histone hyperacetylation, which interferes with Sin3A complex's role in chromatin remodeling and gene regulation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
inhibits HDACs, inducing histone hyperacetylation, and indirectly disrupting the Sin3A complex's function as a transcriptional corepressor. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
alters DNA methylation patterns, indirectly affecting Sin3A complex's recruitment and function in gene regulation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is a DNA methyltransferase inhibitor that can change DNA methylation patterns, potentially influencing the Sin3A complex's interactions with chromatin and transcriptional regulation. | ||||||