Sidekick-2 Inhibitors
Inhibitors of Sidekick-2 such as Wnt-C59 and XAV-939 focus on the Wnt/β-catenin pathway, a crucial regulator of gene expression and cell development. By reducing Wnt signaling, these compounds can lead to decreased expression levels of proteins like Sidekick-2 that are potentially regulated by this pathway. Similarly, DAPT can diminish Notch pathway signaling, which has implications for the regulation of proteins involved in neuronal development, including Sidekick-2.
Other compounds such as LY294002 and PD173074 target the PI3K/AKT and FGFR pathways, respectively. These pathways are critical for cell survival, proliferation, and differentiation. By modulating these pathways, the inhibitors can affect the cellular context within which Sidekick-2 operates, potentially leading to changes in its expression and function. U0126 and SB431542 act on the MEK/ERK and TGF-β pathways, both of which play roles in cell growth and neurogenesis. Inhibition of these pathways can lead to alterations in cellular processes that regulate the presence and activity of Sidekick-2. Y-27632 and NSC23766 work by disrupting the organization of the actin cytoskeleton and Rac1-mediated signaling, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
Wnt/β-catenin pathway inhibitor that can decrease Wnt signaling, potentially reducing the expression of proteins like SDK2 that are downstream of this pathway. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
Tankyrase inhibitor that stabilizes Axin by preventing its poly(ADP-ribosyl)ation and promotes β-catenin degradation, potentially reducing SDK2 expression linked to Wnt signaling. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
Notch pathway inhibitor that can decrease Notch signaling, potentially affecting SDK2 expression which is regulated in part by Notch signaling during neuronal development. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that can decrease AKT pathway signaling, potentially altering the cellular processes that influence SDK2 expression and function. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
FGFR inhibitor that can attenuate the signaling responsible for cell differentiation, potentially affecting SDK2 expression in neuronal tissues. | ||||||
SU 5402 | 215543-92-3 | sc-204308 sc-204308A | 1 mg 5 mg | $62.00 $96.00 | 36 | |
Another FGFR inhibitor that can interfere with pathways promoting cell differentiation, possibly influencing SDK2 levels. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
TGF-β receptor inhibitor that can modulate TGF-β signaling, potentially influencing SDK2 expression as this pathway can be involved in neuronal development and maintenance. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor that can affect actin cytoskeleton organization, potentially impacting cellular processes that influence SDK2's role in cell adhesion and synapse formation. | ||||||
SMER28 | 307538-42-7 | sc-222320 | 10 mg | $173.00 | ||
Autophagy stimulator that can enhance the degradation of cellular components, potentially influencing the turnover of SDK2 proteins. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Dopamine receptor antagonist that can influence neurotransmitter signaling pathways, potentially affecting SDK2 expression or function in neuronal cells. | ||||||