Molecular structure of SMER28, CAS Number: 307538-42-7
SMER28 (CAS 307538-42-7)
Alternate Names:
6-Bromo-N-2-propenyl-4-quinazolinamine
Application:
SMER28 is a small molecule modulator of mammalian autophagy
CAS Number:
307538-42-7
Purity:
≥95%
Molecular Weight:
264.12
Molecular Formula:
C11H10BrN3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SMER28 is a small molecule modulator of mammalian autophagy. Enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment and appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance. SMER28 also augments the cytostatic effects of Rapamycin in Saccharomyces cerevisiae and acts as an autophagy stimulator in mammalian cultures in vitro. Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR.
SMER28 (CAS 307538-42-7) References
- Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. | Sarkar, S., et al. 2007. Nat Chem Biol. 3: 331-8. PMID: 17486044
- A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. | Tian, Y., et al. 2011. FASEB J. 25: 1934-42. PMID: 21368103
- The convergence of endosomal and autophagosomal pathways: implications for APP-CTF degradation. | Tian, Y., et al. 2014. Autophagy. 10: 694-6. PMID: 24447917
- Important role of autophagy in endothelial cell response to ionizing radiation. | Kalamida, D., et al. 2014. PLoS One. 9: e102408. PMID: 25010689
- Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors. | Doulatov, S., et al. 2017. Sci Transl Med. 9: PMID: 28179501
- Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms. | Clark, AE., et al. 2018. J Virol. 92: PMID: 29237845
- SMER28 is a mTOR-independent small molecule enhancer of autophagy that protects mouse bone marrow and liver against radiotherapy. | Koukourakis, MI., et al. 2018. Invest New Drugs. 36: 773-781. PMID: 29387992
- SMER28 Attenuates Dopaminergic Toxicity Mediated by 6-Hydroxydopamine in the Rats via Modulating Oxidative Burdens and Autophagy-Related Parameters. | Darabi, S., et al. 2018. Neurochem Res. 43: 2313-2323. PMID: 30288644
- A Review of Diamond-Blackfan Anemia: Current Evidence on Involved Genes and Treatment Modalities. | Tyagi, A., et al. 2020. Cureus. 12: e10019. PMID: 32983714
- (2R,6R)-Hydroxynorketamine Alleviates Electroconvulsive Shock-Induced Learning Impairment by Inhibiting Autophagy. | Zhong, X., et al. 2021. Neuropsychiatr Dis Treat. 17: 297-304. PMID: 33568909
- SMER28 Attenuates PI3K/mTOR Signaling by Direct Inhibition of PI3K p110 Delta. | Kirchenwitz, M., et al. 2022. Cells. 11: PMID: 35626685
- Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. | Wrobel, L., et al. 2022. Nat Commun. 13: 4146. PMID: 35842429
- SMER28 binding to VCP/p97 enhances both autophagic and proteasomal neurotoxic protein clearance. | Wrobel, L., et al. 2023. Autophagy. 19: 1348-1350. PMID: 36036202
- The autophagy inducer SMER28 attenuates microtubule dynamics mediating neuroprotection. | Kirchenwitz, M., et al. 2022. Sci Rep. 12: 17805. PMID: 36284196
Inhibitor of:
4933403O03Rik, AMBRA1, AP3 Adaptor Complex, ASCL5, IRGM, IRGM (immunity-related GTPase family M), KLHL35, Ndfip1, PIG3, Sidekick-2, TRAF4, TRIM43A, ZFP773, and ZSWIM1.Activator of:
BEAN, Cdc4, KRI1, RFPL1, RFPL2, RNF180, RNF214, UFSP1, ULK1, USP9X, and VPS37A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SMER28, 10 mg | sc-222320 | 10 mg | $173.00 |