Sialyl Lewis a Activators
Sialyl Lewis a Activators are a unique class of chemical entities that serve to augment the functionality of Sialyl Lewis a, a carbohydrate marker displayed on certain white blood cells and some malignancies. These activators exert their influence in a two-fold manner: they stimulate the enzymes responsible for the construction of Sialyl Lewis a, and they supply the necessary raw materials needed for its formation.
The substrates such as Galactose, N-Acetylneuraminic Acid, N-Acetylgalactosamine, Fucose, and N-Acetylglucosamine serve as the core components of Sialyl Lewis a. Their availability is critical in fortifying the production of Sialyl Lewis a, as they provide the essential elements for its assembly. Another compound, 2-Deoxy-D-glucose, plays a supportive role by amplifying the supply of these precursor molecules, indirectly contributing to the amplification of Sialyl Lewis a production. Conversely, compounds like Fucoidan, Retinoic Acid, Ascorbic Acid, Epigallocatechin Gallate (EGCG), Dexamethasone, and Thiamine serve a different function. They act to stimulate the enzymes, notably FUT3 and FUT6, that are directly implicated in the synthesis pathway of Sialyl Lewis a. By boosting the activity of these enzymes, these compounds effectively facilitate the increased production and enhanced functionality of Sialyl Lewis a, contributing to the overall effectiveness and presence of this crucial carbohydrate marker.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fucoidan | 9072-19-9 | sc-255187 sc-255187A | 500 mg 10 g | $186.00 $312.00 | 7 | |
Fucoidan, a complex sulfated polysaccharide, can enhance the expression of enzymes like FUT3 and FUT6 that are involved in the biosynthesis of Sialyl Lewis a. By inducing these enzymes, Fucoidan can enhance the presence and functional activity of Sialyl Lewis a. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid is a metabolite of vitamin A that acts as a hormone-like growth factor. It can enhance the expression of enzymes involved in glycosylation, such as FUT3 and FUT6, leading to enhanced synthesis of Sialyl Lewis a. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic Acid (Vitamin C) can up-regulate the expression of enzymes like FUT3 and FUT6 that are involved in the biosynthesis of Sialyl Lewis a. This leads to an increase in Sialyl Lewis a expression and activity. | ||||||
D-Galactose | 59-23-4 | sc-202564 | 100 g | $224.00 | 4 | |
Galactose is a sugar monomer that is a substrate for the enzymes involved in the synthesis of Sialyl Lewis a. Its availability can enhance the production and functional activity of Sialyl Lewis a. | ||||||
N-Acetylneuraminic acid | 131-48-6 | sc-281055A sc-281055 sc-281055D sc-281055B sc-281055C | 1 g 5 g 25 g 100 g 250 g | $82.00 $153.00 $320.00 $572.00 $1336.00 | ||
N-Acetylneuraminic Acid is a sialic acid that is a direct component of Sialyl Lewis a. Increasing its levels can enhance the production and activity of Sialyl Lewis a. | ||||||
N-Acetyl-D-galactosamine | 1811-31-0 | sc-221979 sc-221979A sc-221979C sc-221979B sc-221979D | 10 mg 100 mg 1 g 5 g 50 g | $50.00 $75.00 $262.00 $1020.00 $1300.00 | ||
N-Acetylgalactosamine is a sugar that is a direct component of Sialyl Lewis a. Increasing its levels can enhance the production and activity of Sialyl Lewis a. | ||||||
L-(−)-Fucose | 2438-80-4 | sc-221792 sc-221792A sc-221792B sc-221792C | 10 mg 5 g 50 g 100 g | $30.00 $150.00 $445.00 $824.00 | ||
Fucose is a sugar that is a direct component of Sialyl Lewis a. Increasing its levels can enhance the production and activity of Sialyl Lewis a. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can increase the expression of the FUT3 and FUT6 enzymes, which are involved in the biosynthesis of Sialyl Lewis a. This leads to an increase in Sialyl Lewis a production and activity. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a corticosteroid that can stimulate the expression of enzymes like FUT3 and FUT6 that are involved in the biosynthesis of Sialyl Lewis a, thus enhancing its production and activity. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose can increase the availability of precursors used in the synthesis of Sialyl Lewis a, thus enhancing its production and functional activity. | ||||||