SH3PXD2B Inhibitors
Chemical inhibitors of SH3PXD2B can exert their inhibitory effects through various mechanisms, primarily by targeting the Src family of tyrosine kinases, which are integral to the protein's function. Dasatinib, a potent tyrosine kinase inhibitor, can disrupt the interaction between SH3PXD2B and the Src kinases, thereby impeding the protein's role in podosome formation. Similarly, PP2 and SU6656, both selective Src family kinase inhibitors, are capable of obstructing the kinase activity essential for SH3PXD2B-mediated cytoskeletal rearrangements. Bosutinib and Saracatinib, also tyrosine kinase inhibitors, further contribute to the inhibition of SH3PXD2B by preventing the activation of Src kinases that SH3PXD2B requires for signaling pathways controlling cell structure and movement.
Furthermore, Herbimycin A, an ansamycin antibiotic, targets tyrosine kinases and consequently can hamper SH3PXD2B's role in cytoskeletal organization. Nilotinib, though primarily targeted at BCR-ABL kinases, can also inhibit the Src family kinases and thus indirectly inhibit SH3PXD2B. Ponatinib, another multi-targeted tyrosine kinase inhibitor, and KX2-391, a non-ATP competitive inhibitor of Src kinase, both can disrupt the kinase signaling pathways that are essential for SH3PXD2B's mediation of actin cytoskeleton dynamics. PP1, a selective inhibitor of Src family tyrosine kinases, and WH-4-023, which selectively inhibits Lck and Src family tyrosine kinases, can inhibit the SH3PXD2B by disrupting the Src kinase signaling, impairing the downstream processes SH3PXD2B is involved in within the cell, including cellular motility and invasion.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a tyrosine kinase inhibitor that can inhibit Src family kinases. SH3PXD2B interacts with Src family kinases for podosome formation; hence, dasatinib can inhibit SH3PXD2B function by inhibiting its associated kinases. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an Src family kinase inhibitor. Since SH3PXD2B requires Src kinases for its signaling pathways involved in cytoskeletal rearrangements, PP2 can functionally inhibit SH3PXD2B by inhibiting these kinases. | ||||||
SU6656 | 330161-87-0 | sc-203286 sc-203286A | 1 mg 5 mg | $57.00 $133.00 | 27 | |
SU6656 is a selective Src family kinase inhibitor. It can inhibit SH3PXD2B activity by preventing the activation of Src kinases that SH3PXD2B depends on for its function in actin cytoskeleton organization. | ||||||
Saracatinib | 379231-04-6 | sc-364607 sc-364607A | 10 mg 200 mg | $115.00 $1056.00 | 7 | |
Saracatinib is an inhibitor of Src family tyrosine kinases. It can functionally inhibit SH3PXD2B by inhibiting the Src kinases that SH3PXD2B interacts with in cellular signaling related to the cytoskeleton. | ||||||
Herbimycin A | 70563-58-5 | sc-3516 sc-3516A | 100 µg 1 mg | $277.00 $1532.00 | 13 | |
Herbimycin A is an ansamycin antibiotic that inhibits tyrosine kinases. It can inhibit SH3PXD2B function by targeting the tyrosine kinases that are associated with SH3PXD2B's role in cytoskeletal reorganization. | ||||||
Nilotinib | 641571-10-0 | sc-202245 sc-202245A | 10 mg 25 mg | $209.00 $413.00 | 9 | |
Nilotinib is a tyrosine kinase inhibitor that, although primarily used for BCR-ABL kinases, also inhibits Src family kinases and can thus functionally inhibit SH3PXD2B by inhibiting the kinases it interacts with. | ||||||
AP 24534 | 943319-70-8 | sc-362710 sc-362710A | 10 mg 50 mg | $175.00 $983.00 | 2 | |
Ponatinib is a multi-targeted tyrosine kinase inhibitor. It can inhibit SH3PXD2B by inhibiting Src family kinases, which are essential for SH3PXD2B's signaling in podosome and invadopodia formation. | ||||||
KX2-391 | 897016-82-9 | sc-364520 sc-364520A | 5 mg 50 mg | $180.00 $1140.00 | ||
KX2-391 is a non-ATP competitive inhibitor of Src kinase. It can functionally inhibit SH3PXD2B by inhibiting Src kinase signaling pathways, thereby affecting SH3PXD2B's ability to mediate actin cytoskeleton dynamics. | ||||||
PP 1 | 172889-26-8 | sc-203212 sc-203212A | 1 mg 5 mg | $86.00 $145.00 | 6 | |
PP1 is a potent and selective inhibitor of Src family tyrosine kinases. It can inhibit SH3PXD2B by disrupting the Src kinase signaling that SH3PXD2B utilizes for its functions in cellular motility and invasion. | ||||||
WH-4-023 | 837422-57-8 | sc-507457 | 10 mg | $172.00 | ||
WH-4-023 is a selective inhibitor for Lck and Src family tyrosine kinases. It can inhibit SH3PXD2B function by targeting Src kinases, thereby impairing the downstream signaling processes that SH3PXD2B is involved in within the cell. | ||||||