SH3BGRL3 Inhibitors
Chemical inhibitors of SH3BGRL3 encompass a variety of compounds that target specific kinases and enzymes within cellular signaling pathways. Staurosporine, a broad-spectrum protein kinase inhibitor, can inhibit the phosphorylation process which is vital for the activation and function of SH3BGRL3. By preventing this post-translational modification, Staurosporine disrupts the normal signaling cascades that SH3BGRL3 is involved in. Similar in their mechanism of action, LY294002 and Wortmannin both serve as inhibitors for phosphoinositide 3-kinases (PI3K). By blocking PI3K activity, these inhibitors can reduce the phosphorylation of downstream targets that are crucial for SH3BGRL3 function. Another compound, U0126, functions by inhibiting MEK1/2, which is part of the MAPK/ERK pathway, a pathway that may be essential for SH3BGRL3's role in signaling. This inhibition can disrupt the cascade that leads to the activation of SH3BGRL3. SP600125 adds to the list by targeting c-Jun N-terminal kinase (JNK), altering the activity of transcription factors and other proteins that interact with SH3BGRL3.
Furthermore, SB203580 specifically inhibits p38 MAP kinase, a protein that plays a role in inflammatory responses and cell differentiation. The inhibition of p38 MAP kinase can indirectly influence the functional activity of SH3BGRL3. PD98059, another MEK inhibitor, prevents the activation of ERK, which is also part of the MAPK pathway, and in doing so, it can result in the functional inhibition of SH3BGRL3. Rapamycin, by inhibiting mTOR kinase, can diminish signaling pathways that regulate or influence the function of SH3BGRL3. GF109203X targets protein kinase C (PKC), and its inhibition can lead to a decrease in the functional activity of proteins like SH3BGRL3 that are modulated by PKC-mediated phosphorylation. ZM336372, a Raf kinase inhibitor, can prevent the activation of pathways necessary for SH3BGRL3's function. SL327 and PP2, both inhibitors of MEK and Src family tyrosine kinases respectively, can also inhibit the functional activity of SH3BGRL3 by interfering with its signaling mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine, a known protein kinase inhibitor, can inhibit the phosphorylation process crucial for the activation and function of SH3BGRL3. By inhibiting kinase activity, it can prevent SH3BGRL3 from undergoing necessary post-translational modifications that are required for its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in multiple signaling pathways. By inhibiting PI3K, LY294002 can reduce the phosphorylation of downstream targets that may be crucial for SH3BGRL3 function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 acts as an inhibitor of mitogen-activated protein kinase (MAPK), more specifically MEK. MEK inhibition can disrupt the MAPK/ERK pathway, which may be essential for the functional activity of SH3BGRL3, thereby inhibiting its role in signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is implicated in various cellular processes. Inhibition of JNK can alter the activity of transcription factors and other proteins that interact with SH3BGRL3, thus inhibiting its function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. By inhibiting p38 MAP kinase, SB203580 can disrupt signaling pathways that may indirectly influence the functional activity of SH3BGRL3. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a covalent inhibitor of PI3K. By inhibiting this kinase, Wortmannin can prevent the phosphorylation of proteins within cell signaling pathways that SH3BGRL3 is part of, thereby inhibiting its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that prevents the activation of ERK, which is part of the MAPK pathway. Inhibition of this pathway can result in functional inhibition of SH3BGRL3 by reducing its activation state or preventing its interaction with other signaling molecules. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a kinase involved in cell growth and proliferation. Through mTOR inhibition, rapamycin can diminish signaling pathways that may regulate or influence the function of SH3BGRL3. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X is a protein kinase C (PKC) inhibitor. Since PKC is involved in a multitude of signaling cascades, its inhibition by GF109203X can lead to a decrease in the functional activity of proteins like SH3BGRL3 that are regulated by PKC-mediated phosphorylation. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
SL327 is an inhibitor of MEK, which is critical for the MAPK/ERK pathway. Inhibition of MEK by SL327 can therefore inhibit the functional activity of SH3BGRL3 by interfering with its signaling mechanisms. | ||||||