Set1A Activators
Set1A activators are chemical compounds that target the Set1A histone methyltransferase complex, which is part of the larger COMPASS (Complex of Proteins Associated with Set1) complex. The Set1A complex is primarily responsible for catalyzing the methylation of histone H3 lysine 4 (H3K4), a modification associated with transcriptionally active chromatin. This methylation event is pivotal in the epigenetic control of gene expression, as it marks genes for activation and facilitates the recruitment of various transcriptional regulators.
Set1A activators function by enhancing the enzymatic activity of the Set1A complex, leading to increased levels of H3K4 methylation at target gene loci. This, in turn, results in a more permissive chromatin structure that allows for greater access to the transcriptional machinery, ultimately leading to elevated gene expression.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAM is a methyl donor and a critical co-substrate for Set1A. It provides the methyl group required for Set1A's histone methyltransferase activity. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP serves as an energy source and co-substrate for Set1A. Set1A requires energy to carry out its enzymatic reactions, and ATP provides this energy, facilitating the methylation of histones by Set1A. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can serve as cofactors for various enzymes, including those involved in chromatin modification. While the exact mechanism is complex, zinc ions may stabilize the protein structure of Set1A or directly participate in its catalytic activity, potentially enhancing its function. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
PLP is a cofactor involved in amino acid metabolism. While not a direct activator, it may play a role in the metabolism of methylated histones, indirectly affecting Set1A function by influencing the availability of substrates and cofactors. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a cofactor involved in various redox reactions. Although not a direct activator, its presence may indirectly influence Set1A activity by affecting the overall cellular metabolic state. | ||||||
Coenzyme A | 85-61-0 anhydrous | sc-211123 sc-211123A sc-211123B sc-211123C | 10 mg 25 mg 100 mg 250 mg | $83.00 $135.00 $418.00 $801.00 | 1 | |
CoA plays a role in various metabolic pathways. While not a direct Set1A activator, it may indirectly affect Set1A by participating in cellular processes that regulate the availability of substrates and cofactors required for Set1A's activity. | ||||||