The chemical class referred to as SERHL2 Inhibitors represents a group of compounds specifically designed to selectively target the molecular entity SERHL2. The SERHL2 gene encodes a serine hydrolase-like protein, and its functional roles and cellular pathways are subjects of ongoing research within molecular biology. Inhibitors within the SERHL2 Inhibitors class are intricately engineered molecules with the primary goal of modulating the activity or function of SERHL2, thereby exerting an inhibitory effect. Researchers investigating SERHL2 Inhibitors employ a comprehensive approach, integrating insights from structural biology, medicinal chemistry, and computational modeling to unravel the complex molecular interactions between the inhibitors and the target SERHL2.
Structurally, SERHL2 Inhibitors are characterized by specific molecular features designed to facilitate selective binding to SERHL2. This selectivity is essential to minimize unintended effects on other cellular components, ensuring a focused impact on the intended molecular target. The development of inhibitors within this chemical class involves a thorough exploration of structure-activity relationships, optimization of pharmacokinetic properties, and a deep understanding of the molecular mechanisms associated with SERHL2. As researchers delve deeper into the functional aspects of SERHL2 Inhibitors, the knowledge generated contributes not only to deciphering the specific roles of SERHL2 but also to advancing our broader comprehension of cellular processes and molecular regulation. The exploration of SERHL2 Inhibitors represents a significant avenue for expanding fundamental knowledge in molecular pharmacology and cellular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide is known to inhibit RNA polymerase II, which could lead to a reduction in the transcription of a broad range of genes, including SERHL2. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA and prevents RNA polymerase from progressing, hence reducing transcription of various genes potentially including SERHL2. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin is a potent inhibitor of RNA polymerase II and could reduce the transcription of many genes, which might impact SERHL2 expression. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB inhibits RNA polymerase II-dependent transcription elongation and could consequently decrease SERHL2 gene expression. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $99.00 | 5 | |
Cordycepin terminates mRNA chain elongation due to its resemblance to adenosine but lacking a hydroxyl group, potentially reducing SERHL2 mRNA levels. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B inhibits nuclear export of mRNA by binding to exportin 1, which could result in lower levels of cytoplasmic SERHL2 mRNA. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts mRNA transport by inhibiting the translocation of secretory proteins, indirectly affecting SERHL2 mRNA processing. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is involved in the control of translation initiation, potentially leading to reduced synthesis of many proteins, including SERHL2. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol inhibits cyclin-dependent kinases (CDKs) that are necessary for RNA polymerase II phosphorylation and transcription, which may reduce SERHL2 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can regulate gene expression by activating retinoic acid receptors, which could affect the transcription of SERHL2 depending on the context. | ||||||