SEPT10 Activators

SEPT10 Activators are a class of chemicals that indirectly affect the activity of the protein SEPT10 by modulating cellular processes and signaling pathways related to cytoskeletal dynamics and cell division. These activators encompass a variety of compounds that influence the polymerization and stability of actin filaments and microtubules, critical components of the cytoskeleton that septins, including SEPT10, interact with.

Actin-targeting compounds such as Swinholide A, work by altering actin dynamics, which in turn can modulate the function of SEPT10 by affecting its interactions with the actin cytoskeleton. Microtubule-affecting agents like Paclitaxel and Nocodazole alter the stability and dynamics of microtubules, influencing septin filament assembly and positioning. Compounds such as Forskolin raise intracellular cAMP levels, thereby possibly initiating signaling cascades that could lead to reorganization of the cytoskeleton, affecting septins indirectly. The small molecules ML-141, Y-27632, NSC 23766, and Blebbistatin act on various aspects of cytoskeletal regulation, through pathways involving small GTPases and myosin II, potentially resulting in alterations to septin assembly and function.