SEMA5A Activators
Semaphorin 5A (SEMA5A) is a protein that belongs to the semaphorin family, which is characterized by its role in axonal guidance during neural development. SEMA5A is a secreted and membrane-associated protein that exerts its effects by binding to plexin and neuropilin receptors, influencing neuronal navigation and positioning. Its structure includes a sema domain, which is a common feature in the semaphorin family and is crucial for its signaling function.Beyond its well-established role in the nervous system, SEMA5A is also involved in the immune system, where it regulates immune cell migration and activation. In the context of development, SEMA5A contributes to the patterning of neuronal circuits and has implications in angiogenesis, guiding the growth of blood vessels.
Dysregulation of SEMA5A has been associated with various pathological conditions. In particular, it has been linked to neurodevelopmental disorders, such as autism, where altered SEMA5A expression may disrupt neural connectivity. Additionally, SEMA5A has been implicated in cancer biology, where it can influence tumor angiogenesis and metastasis.SEMA5A's complex role in both health and disease makes it a target of interest for research. Understanding its signaling pathways could lead to novel interventions for neurodevelopmental disorders and cancer.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid regulates gene expression during development and may upregulate SEMA5A as part of neuronal differentiation. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
As a hormone, beta-estradiol can modulate gene expression and may influence SEMA5A levels in hormone-responsive tissues. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP, potentially affecting SEMA5A expression through cAMP response elements. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 has regulatory roles in gene expression and may modulate SEMA5A expression in certain cell types. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can affect various signaling pathways and might influence SEMA5A expression through its anti-inflammatory properties. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
As a glucocorticoid, dexamethasone can modulate immune responses and may alter SEMA5A expression in immune cells. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
TGF-beta is a cytokine that regulates cell growth and differentiation, potentially affecting SEMA5A expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium influences several signaling pathways, including Wnt, which may intersect with SEMA5A regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, as an HDAC inhibitor, can alter chromatin structure and gene expression, potentially affecting SEMA5A levels. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin modulates various signaling pathways and could affect SEMA5A expression through its effects on cellular signaling. | ||||||