SEMA4F Activators
SEMA4F Activators are a specific class of chemical compounds that have gained considerable attention in the field of molecular biology and cellular signaling. These molecules are primarily known for their role in modulating the activity of SEMA4F, a member of the Semaphorin family of proteins. Semaphorins are a diverse group of secreted and membrane-bound proteins that play pivotal roles in axon guidance, cell migration, and immune response regulation during development and in adult tissues. SEMA4F, in particular, is a transmembrane protein that has been identified as an important regulator of cell-cell interactions and signaling processes in various physiological contexts.
The primary function of SEMA4F Activators is to enhance the biological activity of SEMA4F by binding to specific sites on the protein and initiating downstream signaling events. These activators can exert their effects through various mechanisms, including allosteric modulation or by promoting the interaction of SEMA4F with its cognate receptors. This activation of SEMA4F can have a profound impact on cellular processes, such as axonal guidance, cell migration, and immune cell activation. Understanding the molecular mechanisms and structural aspects of SEMA4F Activators is of great significance in unraveling the intricate web of cellular communication and signaling events that govern various biological processes. While the specific details of SEMA4F Activators' structure and function continue to be a subject of research, their role in regulating SEMA4F activity offers a promising avenue for further exploration in the realms of cellular biology and molecular signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P binds to its receptors, initiating a signaling cascade that includes the activation of the Rho family of GTPases. SEMA4F is known to interact with Plexin-B receptors, which can be regulated by Rho-GTPase signaling. Therefore, S1P's action can indirectly lead to the activation of SEMA4F by modulating Rho-GTPase activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP can activate PKA, which may phosphorylate substrates that interact with SEMA4F or its receptors, indirectly enhancing SEMA4F signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium levels. Elevated intracellular calcium can activate calcium-sensitive signaling pathways that SEMA4F may be a part of, indirectly enhancing its functional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits several protein kinases, potentially reducing competitive signaling and allowing SEMA4F-mediated pathways to be more active. This can lead to an indirect enhancement of SEMA4F's functional role in axonal growth or cell migration. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
FTY720 is phosphorylated in vivo to form FTY720-phosphate, which can act as an S1P receptor modulator. This modulation can lead to alterations in Rho-GTPase signaling, which could indirectly activate SEMA4F through its interactions with Plexin-B receptors. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA interacts with its G protein-coupled receptors to activate Rho-GTPase among other signaling pathways. This activation can indirectly lead to the enhancement of SEMA4F activity, given that SEMA4F signaling is modulated by Rho-GTPase activity. | ||||||
Wnt Agonist | 853220-52-7 | sc-222416 sc-222416A | 5 mg 25 mg | $154.00 $597.00 | 23 | |
Wnt Agonist 1 promotes Wnt signaling, which can intersect with SEMA4F signaling pathways, particularly in the context of neuronal development and axonal growth. This can indirectly enhance SEMA4F's functional role in these processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can influence numerous pathways, including those involving SEMA4F. Activation of PKC might lead to downstream effects that enhance SEMA4F signaling indirectly. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, leading to reduced ERK pathway activity. SEMA4F is implicated in pathways that can be negatively regulated by ERK signaling. Inhibition of MEK1/2 by U0126 could therefore create a signaling environment that indirectly enhances SEMA4F function. | ||||||
CCG-1423 | 285986-88-1 | sc-205241 sc-205241A | 1 mg 5 mg | $30.00 $90.00 | 8 | |
CCG-1423 inhibits the RhoA/serum response factor (SRF) transcriptional pathway. Since SEMA4F is known to interact with receptors that can influence Rho-GTPase activity, inhibition of RhoA/SRF by CCG-1423 could create a favorable condition for SEMA4F signaling to be enhanced. | ||||||